Downregulation of gelsolin family proteins counteracts cancer cell invasion in vitro

被引：85

作者：

van den Abbeele, Anske

De Corte, Veerle

Van Impe, Katrien

Bruyneel, Erik

Bottcherie, Ciska

Bracke, Marc

Vandekerckhove, Joel

Gettemans, Jan

机构：

[1] Univ Ghent, Fac Med & Hlth Sci, Dept Med Prot Res, B-9000 Ghent, Belgium

[2] Univ Ghent, Fac Med & Hlth Sci, Dept Biochem & Mol Biol, B-9000 Ghent, Belgium

[3] State Univ Ghent Hosp, Dept Radiotherapy & Nucl Med, Lab Expt Cancerol, B-9000 Ghent, Belgium

来源：

CANCER LETTERS | 2007年 / 255卷 / 01期

关键词：

CapG; gelsolin; siRNA; invasion; cell aggregation; cytoskeleton; cancer cell;

D O I：

10.1016/j.canlet.2007.03.023

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Gelsolin and CapG are both actin binding proteins that modulate a variety of physiological processes by interacting differently with the actin cytoskeleton. Several studies suggest that overexpression of these proteins promotes invasion in vitro. In this study we explored the contribution of these proteins in human cancer cell invasion and motility. We show that down regulation of CapG or gelsolin in several types of cancer cells, including MDA-MB 231 and PC-3 cells, significantly reduces the invasive and motile properties of cells, as well as cell aggregation. These results point to a role for CapG and gelsolin as tumor activator. (c) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：57 / 70

页数：14

共 61 条

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