DNA replication and transcription in mammalian mitochondria

被引:502
作者
Falkenberg, Maria [1 ]
Larsson, Nils-Goeran [1 ]
Gustafsson, Claes M. [1 ]
机构
[1] Karolinska Inst, Div Metab Dis, SE-14186 Stockholm, Sweden
关键词
bacteriophage; DNA replication; evolution; mitochondrion; transcription;
D O I
10.1146/annurev.biochem.76.060305.152028
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The mitochondrion was originally a free-living prokaryotic organism, which explains the presence of a compact mammalian mitochondrial DNA (mtDNTA) in contempory mammalian cells. The genome encodes for key subunits of the electron transport chain and RNA components needed for mitochondrial translation. Nuclear genes encode the enzyme Systems responsible for mtDNA replication and transcription. Several of the key components of these systems are related to proteins replicating and transcribing DNA in bacterio-phages. This observation has led to the proposition that some genes required for DNA replication and transcription were acquired together from a phage early in the evolution of the eukaryotic cell, already at the time of the mitochondrial endosymbiosis. Recent years have seen a rapid development in our molecular understanding of these machineries, but many aspects still remain unknown.
引用
收藏
页码:679 / 699
页数:21
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