Moderate Exercise Training Attenuates the Severity of Experimental Rodent Colitis: The Importance of Crosstalk between Adipose Tissue and Skeletal Muscles

被引：47

作者：

Bilski, Jan ^{[1
]}

Mazur-Bialy, Agnieszka I. ^{[1
]}

Brzozowski, Bartosz ^{[2
]}

Magierowski, Marcin ^{[3
]}

Jasnos, Katarzyna ^{[3
]}

Krzysiek-Maczka, Gracjana ^{[3
]}

Urbanczyk, Katarzyna ^{[4
]}

Ptak-Belowska, Agata ^{[3
]}

Zwolinska-Wcislo, Malgorzata ^{[2
]}

Mach, Tomasz ^{[2
]}

Brzozowski, Tomasz ^{[3
]}

机构：

[1] Jagiellonian Univ, Fac Hlth Care, Dept Phys Exercise, Coll Med, PL-31531 Krakow, Poland

[2] Jagiellonian Univ, Gastroenterol & Hepatol Clin, Coll Med, PL-31501 Krakow, Poland

[3] Jagiellonian Univ, Coll Med, Dept Physiol, Fac Med, PL-31531 Krakow, Poland

[4] Jagiellonian Univ, Coll Med, Dept Pathomorphol, Fac Med, PL-31531 Krakow, Poland

来源：

MEDIATORS OF INFLAMMATION | 2015年 / 2015卷

关键词：

INFLAMMATORY BOWEL DISEASES; C-REACTIVE PROTEIN; CROHNS-DISEASE; ULCERATIVE-COLITIS; TWEAK/FN14; PATHWAY; MESENTERIC FAT; PROINFLAMMATORY CYTOKINES; BACTERIAL TRANSLOCATION; INSULIN-RESISTANCE; GUT INFLAMMATION;

D O I：

10.1155/2015/605071

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Although progress has been recently made in understanding of inflammatory bowel diseases (IBD), their etiology is unknown apart from several factors from adipose tissue and skeletal muscles such as cytokines, adipokines, and myokines were implicated in the pathogenesis of ulcerative colitis. We studied the effect high-fat diet (HFD; cholesterol up to 70%), low-fat diet (LFD; cholesterol up to 10%), and the normal diet (total fat up to 5%) in rats with TNBS colitis forced to treadmill running exercise (5 days/week) for 6 weeks. In nonexercising HFD rats, the area of colonic damage, colonic tissue weight, the plasma IL-1 beta, TNF-alpha, TWEAK, and leptin levels, and the expression of IL-1 beta-, TNF-alpha-, and Hif1 alpha mRNAs were significantly increased and a significant fall in plasma adiponectin and irisin levels was observed as compared to LFD rats. In HFD animals, the exercise significantly accelerated the healing of colitis, raised the plasma levels of IL-6 and irisin, downregulated the expression of IL-1 beta, TNF-alpha, and Hif1 alpha, and significantly decreased the plasma IL-1 beta, TNF alpha, TWEAK, and leptin levels. We conclude that HFD delays the healing of colitis in trained rats via decrease in CBF and plasma IL-1 beta, TNF-alpha, TWEAK, and leptin levels and the release of protective irisin.

引用

页数：12

共 62 条

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