Genetic Polymorphisms of the CACNA2D1 Gene and Their Association with Carcass and Meat Quality Traits in Cattle

被引：20

作者：

Hou, Guan-Yu ^{[1
,2
]}

Yuan, Zheng-Rong ^{[1
]}

Gao, Xue ^{[1
]}

Li, Jun-Ya ^{[1
]}

Gao, Hui-Jiang ^{[1
]}

Chen, Jin-Bao ^{[1
]}

Xu, Shang-Zhong ^{[1
]}

机构：

[1] Chinese Acad Agr Sci, Lab Mol Biol & Bovine Breeding, Key Lab Farm Anim Genet Resources & Utilizat, Minist Agr,Inst Anim Sci, Beijing 100193, Peoples R China

[2] NW A&F Univ, Coll Anim Sci & Technol, Yangling 712100, Shaanxi, Peoples R China

来源：

BIOCHEMICAL GENETICS | 2010年 / 48卷 / 9-10期

关键词：

Cattle; CACNA2D1; gene; Carcass and meat quality traits; SNPs; Association analysis; IDENTICAL-BY-DESCENT; CENTRAL CORE DISEASE; MALIGNANT HYPERTHERMIA; LOCI; IDENTIFICATION; GROWTH; CHROMOSOME-4; QTL;

D O I：

10.1007/s10528-010-9357-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The objective of this study was to identify genetic polymorphisms of the CACNA2D1 gene and to analyze associations between SNPs and carcass and meat quality traits in cattle. Through PCR-RFLP and DNA sequencing methods, a new allelic variant corresponding to the A -> G mutation (aspartic to glycine amino acid replacement) of the bovine CACNA2D1 gene was detected. Two alleles and three genotypes (AA, AG, and GG) were defined. Genetic character indicated that the A526745G locus showed moderate polymorphism and was in Hardy-Weinberg equilibrium. Gene-specific SNP marker association analysis showed that the A526745G mutant was significantly associated with carcass weight, dressing percentage, meat percentage, and backfat thickness. The results add new evidence that CACNA2D1 is an important candidate gene for the selection of carcass and meat quality traits in the cattle industry.

引用

页码：751 / 759

页数：9

共 24 条

[1] GENETIC-MAPPING OF QUANTITATIVE TRAIT LOCI FOR GROWTH AND FATNESS IN PIGS [J].