Visible fluorescence chemosensor for saxitoxin

被引：80
作者：
Gawley, Robert E. [1 ]
Mao, Hua [1 ]
Haque, M. Mahbubul [1 ]
Thorne, John B. [1 ]
Pharr, Jennifer S. [1 ]
机构：
[1] Univ Arkansas, Dept Chem & Biochem, Fayetteville, AR 72701 USA
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2007年 / 72卷 / 06期
关键词：
D O I：
10.1021/jo062506r
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Absorption spectra of a number of shellfish extracts have been obtained and reveal prominent absorptions in all samples at 210 and 260 nm and at 325 nm in some of them. These absorptions preclude the use of chromophores with similar absorptions in testing of shellfish samples for paralytic shellfish toxins. Two crown ether chemosensors featuring a boron azadipyrrin chromophore have been synthesized; both have absorption maxima at 650 nm, where all the shellfish extracts are transparent. The synthetic sensors feature either 18- or 27-membered crown ether rings and have been evaluated as visible sensors for the paralytic shellfish toxin saxitoxin. The binding constant for one of them is in the range of 3-9 x 10(5) M-1 and exhibits a fluorescence enhancement of over 100% at 680 nm in the presence of 40 mu M saxitoxin.
引用
收藏
页码：2187 / 2191
页数：5
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