A novel peptide-based recognition probe for the sensitive detection of CD44 on breast cancer stem cells

被引：13

作者：

Cho, Jun-Haeng ^{[1
,2
]}

Lee, Sang-Choon ^{[1
,2
]}

Ha, Na-Reum ^{[1
,2
]}

Lee, Su-Jae ^{[3
]}

Yoon, Moon-Young ^{[1
,2
]}

机构：

[1] Hanyang Univ, Dept Chem, Seoul 133791, South Korea

[2] Hanyang Univ, Res Inst Nat Sci, Seoul 133791, South Korea

[3] Hanyang Univ, Dept Life Sci, Seoul 133791, South Korea

来源：

MOLECULAR AND CELLULAR PROBES | 2015年 / 29卷 / 06期

关键词：

CD44; Breast cancer stem cell; Peptide; PDPP; HYALURONAN; MACROMOLECULES; RESISTANCE; TARGETS; BRAIN;

D O I：

10.1016/j.mcp.2015.05.014

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Metastasis and recurrence of breast cancer remain significant clinical problems. The expression level of CD44 protein is higher in breast cancer-initiating cancer stem cells; therefore, the early detection of CD44 using a sensitive diagnostic probe is important for breast cancer diagnosis and therapeutic purposes. In this study, we fabricated a polyvalent directed peptide polymer (PDPP) that specifically recognized the CD44 biomarker, as confirmed by immunocytochemistry tests and fluorescence-activated cell sorting assessment. Our results indicate that PDPP is useful as a novel tool for the sensitive detection of breast cancer stem cells. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：492 / 499

页数：8

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