A novel peptide-based recognition probe for the sensitive detection of CD44 on breast cancer stem cells

被引：14
作者：
Cho, Jun-Haeng [1 ,2 ]
Lee, Sang-Choon [1 ,2 ]
Ha, Na-Reum [1 ,2 ]
Lee, Su-Jae [3 ]
Yoon, Moon-Young [1 ,2 ]
机构：
[1] Hanyang Univ, Dept Chem, Seoul 133791, South Korea
[2] Hanyang Univ, Res Inst Nat Sci, Seoul 133791, South Korea
[3] Hanyang Univ, Dept Life Sci, Seoul 133791, South Korea
来源：
MOLECULAR AND CELLULAR PROBES | 2015年 / 29卷 / 06期
关键词：
CD44; Breast cancer stem cell; Peptide; PDPP; HYALURONAN; MACROMOLECULES; RESISTANCE; TARGETS; BRAIN;
D O I：
10.1016/j.mcp.2015.05.014
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Metastasis and recurrence of breast cancer remain significant clinical problems. The expression level of CD44 protein is higher in breast cancer-initiating cancer stem cells; therefore, the early detection of CD44 using a sensitive diagnostic probe is important for breast cancer diagnosis and therapeutic purposes. In this study, we fabricated a polyvalent directed peptide polymer (PDPP) that specifically recognized the CD44 biomarker, as confirmed by immunocytochemistry tests and fluorescence-activated cell sorting assessment. Our results indicate that PDPP is useful as a novel tool for the sensitive detection of breast cancer stem cells. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：492 / 499
页数：8
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