From bench to bedside: mGluR2 positive allosteric modulators as medications to treat substance use disorders

被引：11
作者：
Acri, Jane B. [1 ]
Cross, Alan J. [2 ]
Skolnick, Phil [1 ]
机构：
[1] NIDA, Div Therapeut & Med Consequences, 6001 Execut Blvd,Suite 4123,MSC 9551, Bethesda, MD 20892 USA
[2] AstraZeneca Neurosci Innovat Med & Early Dev Biot, 141 Portland St, Cambridge, MA 02139 USA
来源：
PSYCHOPHARMACOLOGY | 2017年 / 234卷 / 9-10期
关键词：
Athina Markou; mGluR2; Cocaine; Nicotine; Glutamate; Self-administration; Cue-induced reinstatement; Animal models; Smoking cessation; METABOTROPIC GLUTAMATE RECEPTORS; AGONIST LY379268; INDUCED REINSTATEMENT; SEEKING BEHAVIOR; DRUG-SEEKING; COCAINE; NICOTINE; ADDICTION; REWARD; DOPAMINE;
D O I：
10.1007/s00213-016-4501-9
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
This paper provides an overview of the role of type 2 metabotropic glutamate receptors (mGluR2) in addiction and behaviors reflecting addictive processes. AZD8529, an mGluR2 positive allosteric modulator (PAM), failed to separate from placebo in a phase II schizophrenia trial. The demonstration by Athina Markou's laboratory that AZD8529 attenuated both nicotine self-administration and cue-induced reinstatement was a key factor in the decision to move this compound into a smoking cessation study. Here, we highlight Markou laboratory's contribution to this project, as well as several innovative features of the phase II clinical trial that has already completed enrollment with top line results expected in early 2017.
引用
收藏
页码：1347 / 1355
页数：9
相关论文
共 66 条
  • [31] The mGluR2 Positive Allosteric Modulator BINA Decreases Cocaine Self-Administration and Cue-Induced Cocaine-Seeking and Counteracts Cocaine-Induced Enhancement of Brain Reward Function in Rats
    Jin, Xinchun
    Semenova, Svetlana
    Yang, Li
    Ardecky, Robert
    Sheffler, Douglas J.
    Dahl, Russell
    Conn, P. Jeffrey
    Cosford, Nicholas D. P.
    Markou, Athina
    [J]. NEUROPSYCHOPHARMACOLOGY, 2010, 35 (10) : 2021 - 2036
  • [32] Differential effects of the metabotropic glutamate 2/3 receptor agonist LY379268 on nicotine versus cocaine self-administration and relapse in squirrel monkeys
    Justinova, Zuzana
    Le Foll, Bernard
    Redhi, Godfrey H.
    Markou, Athina
    Goldberg, Steven R.
    [J]. PSYCHOPHARMACOLOGY, 2016, 233 (10) : 1791 - 1800
  • [33] The Novel Metabotropic Glutamate Receptor 2 Positive Allosteric Modulator, AZD8529, Decreases Nicotine Self-Administration and Relapse in Squirrel Monkeys
    Justinova, Zuzana
    Panlilio, Leigh V.
    Secci, Maria E.
    Redhi, Godfrey H.
    Schindler, Charles W.
    Cross, Alan J.
    Mrzljak, Ladislav
    Medd, Amy
    Shaham, Yavin
    Goldberg, Steven R.
    [J]. BIOLOGICAL PSYCHIATRY, 2015, 78 (07) : 452 - 462
  • [34] The neural basis of addiction: A pathology of motivation and choice
    Kalivas, PW
    Volkow, ND
    [J]. AMERICAN JOURNAL OF PSYCHIATRY, 2005, 162 (08) : 1403 - 1413
  • [35] A metabotropic glutamate 2/3 receptor antagonist, MGS0039, increases extracellular dopamine levels in the nucleus accumbens shell
    Karasawa, JI
    Yoshimizu, T
    Chaki, S
    [J]. NEUROSCIENCE LETTERS, 2006, 393 (2-3) : 127 - 130
  • [36] Prefrontal synaptic markers of cocaine addiction-like behavior in rats
    Kasanetz, F.
    Lafourcade, M.
    Deroche-Gamonet, V.
    Revest, J-M
    Berson, N.
    Balado, E.
    Fiancette, J-F
    Renault, P.
    Piazza, P-V
    Manzoni, O. J.
    [J]. MOLECULAR PSYCHIATRY, 2013, 18 (06) : 729 - 737
  • [37] Prefrontal-striatal pathway underlies cognitive regulation of craving
    Kober, Hedy
    Mende-Siedlecki, Peter
    Kross, Ethan F.
    Weber, Jochen
    Mischel, Walter
    Hart, Carl L.
    Ochsner, Kevin N.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (33) : 14811 - 14816
  • [38] Cue-induced brain activity changes and relapse in cocaine-dependent patients
    Kosten, TR
    Scanley, BE
    Tucker, KA
    Oliveto, A
    Prince, C
    Sinha, R
    Potenza, MN
    Skudlarski, P
    Wexler, BE
    [J]. NEUROPSYCHOPHARMACOLOGY, 2006, 31 (03) : 644 - 650
  • [39] Kosten TR., 1992, AM J ADDICTION, V1, P230, DOI [DOI 10.1111/J.1521-0391.1992.TB00029.X, 10.3109/10550499209004025, DOI 10.3109/10550499209004025]
  • [40] Attenuation of nicotine-taking and nicotine-seeking behavior by the mGlu2 receptor positive allosteric modulators AZD8418 and AZD8529 in rats
    Li, Xia
    D'Souza, Manoranjan S.
    Nino, Ana M.
    Doherty, James
    Cross, Alan
    Markou, Athina
    [J]. PSYCHOPHARMACOLOGY, 2016, 233 (10) : 1801 - 1814
1234567