Agrin in the developing CNS:: New roles for a synapse organizer

被引：44
作者：
Kröger, S [1 ]
Schröder, JE [1 ]
机构：
[1] Univ Mainz, Inst Physiol Chem & Pathobiochem, D-55099 Mainz, Germany
来源：
NEWS IN PHYSIOLOGICAL SCIENCES | 2002年 / 17卷
关键词：
D O I：
10.1152/01390.2002
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
The heparan sulfate proteoglycan agrin is responsible for the formation, maintenance, and regeneration of the neuromuscular junction. In the central nervous system, agrin is widely expressed and concentrated at interneuronal synapses, but its function during synaptogenesis remains controversial. Instead, evidence for additional functions of agrin during axonal growth, establishment of the blood-brain barrier, and Alzheimer's disease is accumulating.
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页码：207 / 212
页数：6
相关论文
共 21 条
[1]  
Barber AJ, 1997, DEV DYNAM, V208, P62, DOI 10.1002/(SICI)1097-0177(199701)208:1<62::AID-AJA6>3.0.CO
[2]  
2-#
[3]   The neurobiology of Duchenne muscular dystrophy:: learning lessons from muscle? [J].
Blake, DJ ;
Kröger, S .
TRENDS IN NEUROSCIENCES, 2000, 23 (03) :92-99
[4]  
Böse CM, 2000, J NEUROSCI, V20, P9086
[5]   Agrin isoforms with distinct amino termini: Differential expression, localization, and function [J].
Burgess, RW ;
Skarnes, WC ;
Sanes, JR .
JOURNAL OF CELL BIOLOGY, 2000, 151 (01) :41-52
[6]   Agrin binds to β-amyloid (Aβ), accelerates Aβ fibril formation, and is localized to AB deposits in Alzheimer's disease brain [J].
Cotman, SL ;
Halfter, W ;
Cole, GJ .
MOLECULAR AND CELLULAR NEUROSCIENCE, 2000, 15 (02) :183-198
[7]  
Halfter W, 1997, J COMP NEUROL, V383, P1
[8]   Evidence of an agrin receptor in cortical neurons [J].
Hilgenberg, LGW ;
Hoover, CL ;
Smith, MA .
JOURNAL OF NEUROSCIENCE, 1999, 19 (17) :7384-7393
[9]   Agrin regulates neuronal responses to excitatory neurotransmitters in vitro and in vivo [J].
Hilgenberg, LGW ;
Ho, KD ;
Lee, D ;
O'Dowd, DK ;
Smith, MA .
MOLECULAR AND CELLULAR NEUROSCIENCE, 2002, 19 (01) :97-110
[10]  
Ji RR, 1998, J NEUROSCI, V18, P9695
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