HIV-1 proteins join the family of LIM kinase partners. New roads open up for HIV-1 treatment

被引：13

作者：

Manetti, Fabrizio ^{[1
]}

机构：

[1] Dipartimento Farmaco Chim Tecnol, I-53100 Siena, Italy

来源：

DRUG DISCOVERY TODAY | 2012年 / 17卷 / 1-2期

关键词：

STABLE MICROTUBULE FORMATION; COFILIN-PHOSPHORYLATION; CANCER CELLS; T-CELLS; RETROVIRAL INFECTION; ACTIN; INHIBITORS; MOESIN; TUMOR; PATHWAY;

D O I：

10.1016/j.drudis.2011.08.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

LIM kinases (LIMK) exert their functions by recruiting many macromolecular partners that could contribute to modulate LIMK activity in a positive or negative manner. In addition to proteins that interact with LIMK in human or animal cells and tissues, recent data show that LIMK activity is also influenced by HIV-1 viral proteins. These results suggest new strategies for the treatment of HIV-1 infection, based on the inhibition of LIMK-mediated cofilin inactivation and consequent actin depolymerization. Further efforts are however required to unravel the mechanism by which the virus interferes with LIMK activity and with the right balance of actin remodeling.

引用

页码：81 / 88

页数：8

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