HIV-1 proteins join the family of LIM kinase partners. New roads open up for HIV-1 treatment

被引：13

作者：

Manetti, Fabrizio ^{[1
]}

机构：

[1] Dipartimento Farmaco Chim Tecnol, I-53100 Siena, Italy

来源：

DRUG DISCOVERY TODAY | 2012年 / 17卷 / 1-2期

关键词：

STABLE MICROTUBULE FORMATION; COFILIN-PHOSPHORYLATION; CANCER CELLS; T-CELLS; RETROVIRAL INFECTION; ACTIN; INHIBITORS; MOESIN; TUMOR; PATHWAY;

D O I：

10.1016/j.drudis.2011.08.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

LIM kinases (LIMK) exert their functions by recruiting many macromolecular partners that could contribute to modulate LIMK activity in a positive or negative manner. In addition to proteins that interact with LIMK in human or animal cells and tissues, recent data show that LIMK activity is also influenced by HIV-1 viral proteins. These results suggest new strategies for the treatment of HIV-1 infection, based on the inhibition of LIMK-mediated cofilin inactivation and consequent actin depolymerization. Further efforts are however required to unravel the mechanism by which the virus interferes with LIMK activity and with the right balance of actin remodeling.

引用

页码：81 / 88

页数：8

共 60 条

[1] A PAK4-LIMK1 pathway drives prostate cancer cell migration downstream of HGF [J].

Ahmed, Tasneem ;

Shea, Kerry ;

Masters, John R. W. ;

Jones, Gareth E. ;

Wells, Claire M. .

CELLULAR SIGNALLING, 2008, 20 (07) :1320-1328

[2] A haplotype spanning two genes, ELN and LIMK1, decreases their transcripts and confers susceptibility to intracranial aneurysms [J].

Akagawa, H ;

Tajima, A ;

Sakamoto, Y ;

Krischek, B ;

Yoneyama, T ;

Kasuya, H ;

Onda, H ;

Hori, T ;

Kubota, M ;

Machida, T ;

Saeki, N ;

Hata, A ;

Hashiguchi, K ;

Kimura, E ;

Kim, CJ ;

Yang, TK ;

Lee, JY ;

Kimm, K ;

Inoue, I .

HUMAN MOLECULAR GENETICS, 2006, 15 (10) :1722-1734

[3] LIM kinase 1 increases tumor metastasis of human breast cancer cells via regulation of the urokinase-type plasminogen activator system [J].

Bagheri-Yarmand, R ;

Mazumdar, A ;

Sahin, AA ;

Kumar, R .

INTERNATIONAL JOURNAL OF CANCER, 2006, 118 (11) :2703-2710

[4] Moesin is required for HIV-1-induced CD4-CXCR4 interaction, F-actin redistribution, membrane fusion and viral infection in lymphocytes [J].

Barrero-Villar, Marta ;

Roman Cabrero, Jose ;

Gordon-Alonso, Monica ;

Barroso-Gonzalez, Jonathan ;

Alvarez-Losada, Susana ;

Angeles Munoz-Fernandez, M. ;

Sanchez-Madrid, Francisco ;

Valenzuela-Fernandez, Agustin .

JOURNAL OF CELL SCIENCE, 2009, 122 (01) :103-113

[5] How to engage Cofilin [J].

Bukrinsky, Michael .

RETROVIROLOGY, 2008, 5 (1)

[6] Establishment of HIV-1 latency in resting CD4+ T cells depends on chemokine-induced changes in the actin cytoskeleton [J].

Cameron, Paul U. ;

Saleh, Suha ;

Sallmann, Georgina ;

Solomon, Ajantha ;

Wightman, Fiona ;

Evans, Vanessa A. ;

Boucher, Genevieve ;

Haddad, Elias K. ;

Sekaly, Rafick-Pierre ;

Harman, Andrew N. ;

Anderson, Jenny L. ;

Jones, Kate L. ;

Mak, Johnson ;

Cunningham, Anthony L. ;

Jaworowski, Anthony ;

Lewin, Sharon R. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (39) :16934-16939

[7] Loss of Modifier of Cell Adhesion Reveals a Pathway Leading to Axonal Degeneration [J].

Chen, Qi ;

Peto, Charles A. ;

Shelton, G. Diane ;

Mizisin, Andrew ;

Sawchenko, Paul E. ;

Schubert, David .

JOURNAL OF NEUROSCIENCE, 2009, 29 (01) :118-130

[8] Par-3 mediates the inhibition of LIM kinase 2 to regulate cofilin phosphorylation and tight junction assembly [J].

Chen, XY ;

Macara, IG .

JOURNAL OF CELL BIOLOGY, 2006, 172 (05) :671-678

[9]

Chen YT, 2010, 239 ACS NAT M SAN FR

[10] YB-1 evokes susceptibility to cancer through cytokinesis failure, mitotic dysfunction and HER2 amplification [J].

Davies, A. H. ;

Barrett, I. ;

Pambid, M. R. ;

Hu, K. ;

Stratford, A. L. ;

Freeman, S. ;

Berquin, I. M. ;

Pelech, S. ;

Hieter, P. ;

Maxwell, C. ;

Dunn, S. E. .

ONCOGENE, 2011, 30 (34) :3649-3660

← 1 2 3 4 5 6 →