Sertraline promotes hippocampus-derived neural stem cells differentiating into neurons but not glia and attenuates LPS-induced cellular damage

被引：21
作者：
Peng, Zheng-Wu [1 ]
Xue, Yun-Yun [1 ]
Wang, Hua-Ning [1 ]
Wang, Huai-Hai [1 ]
Xue, Fen [1 ]
Kuang, Fang [2 ]
Wang, Bai-Ren [2 ]
Chen, Yun-Chun [1 ]
Zhang, Li-Yi [3 ]
Tan, Qing-Rong [1 ]
机构：
[1] Fourth Mil Med Univ, Xijing Hosp, Dept Psychosomat Med, Xian 710032, Peoples R China
[2] Fourth Mil Med Univ, Inst Neurosci, Xian 710032, Peoples R China
[3] 102 Hosp, Changzhou 213003, Peoples R China
来源：
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2012年 / 36卷 / 01期
关键词：
Neural stem cells; Neuronal differentiation; Neuroprotective effect; Sertraline; NECROSIS-FACTOR-ALPHA; MAJOR DEPRESSION; INCREASES NEUROGENESIS; ANTIDEPRESSANT ACTION; HUNTINGTONS-DISEASE; INDUCED APOPTOSIS; ADULT BRAIN; MOUSE MODEL; FLUOXETINE; EXPRESSION;
D O I：
10.1016/j.pnpbp.2011.08.014
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Sertraline is one of the most commonly used antidepressants in clinic. Although it is well accepted that sertraline exerts its action through inhibition of the reuptake of serotonin at presynaptic site in the brain, its effect on the neural stem cells (NSCs) has not been well elucidated. In this study, we utilized NSCs separated from the hippocampus of fetal rat to investigate the effect of sertraline on the proliferation and differentiation of NSCs. The study demonstrated that sertraline had no effect on NSCs proliferation but it significantly promoted NSCs to differentiate into serotoninergic neurons other than glia cells. Furthermore, we found that sertraline protected NSCs against the lipopolysaccharide-induced cellular damage. These data indicate that sertraline can promote neurogenesis and protect the viability of neural stem cells. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码：183 / 188
页数：6
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