A RAVE about opioid withdrawal

被引：23

作者：

Alvarez, V ^{[1
]}

Arttamangkul, S

Williams, JT

机构：

[1] Harvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 USA

[2] Oregon Hlth Sci Univ, Vollum Inst, Portland, OR 97201 USA

来源：

NEURON | 2001年 / 32卷 / 05期

关键词：

D O I：

10.1016/S0896-6273(01)00530-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Control of trafficking of g protein-linked receptors is thought to be an important regulatory mechanism for receptor signaling. Finn and Whistler test the hypothesis that agonist-induced trafficking of opioid receptors regulates the development of tolerance and dependence. The results show that measures of tolerance and withdrawal to morphine are decreased under conditions where receptors are trafficked through the endocytic/recycling pathway.

引用

页码：761 / 763

页数：3

共 12 条

[1] Regulation of opioid receptor function by chronic agonist exposure: Constitutive activity and desensitization [J].

Chavkin, C ;

McLaughlin, JP ;

Celver, JP .

MOLECULAR PHARMACOLOGY, 2001, 60 (01) :20-25

[2]

Chieng B, 1998, J NEUROSCI, V18, P7033

[3] Endocytosis of the mu opioid receptor reduces tolerance and a cellular hallmark of opiate withdrawal [J].

Finn, AK ;

Whistler, JL .

NEURON, 2001, 32 (05) :829-839

[4] Changes in the expression of G protein-coupled receptor kinases and β-arrestin 2 in rat brain during opioid tolerance and supersensitivity [J].

Hurlé, MA .

JOURNAL OF NEUROCHEMISTRY, 2001, 77 (02) :486-492

[5]

Ingram SL, 1998, J NEUROSCI, V18, P10269

[6]

JOHNSON SM, 1989, PHARMACOL REV, V41, P435

[7] Overexpression of dynamin is induced by chronic stimulation of μ- but not δ-opioid receptors:: Relationships with μ-related morphine dependence [J].

Noble, F ;

Szücs, M ;

Kieffer, B ;

Roques, BP .

MOLECULAR PHARMACOLOGY, 2000, 58 (01) :159-166

[8] μ-opioid receptor downregulation contributes to opioid tolerance in vivo [J].

Stafford, K ;

Gomes, AB ;

Shen, J ;

Yoburn, BC .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2001, 69 (1-2) :233-237

[9] Functional dissociation of μ opioid receptor signaling and endocytosis:: Implications for the biology of opiate tolerance and addiction [J].

Whistler, JL ;

Chuang, HH ;

Chu, P ;

Jan, LY ;

von Zastrow, M .

NEURON, 1999, 23 (04) :737-746

[10] Morphine-activated opioid receptors elude desensitization by β-arrestin [J].

Whistler, JL ;

von Zastrow, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (17) :9914-9919

← 1 2 →