Bismuth nitrate-catalyzed multicomponent reaction for efficient and one-pot synthesis of densely functionalized piperidine scaffolds at room temperature

被引：162

作者：

Brahmachari, Goutam ^{[1
]}

Das, Suvankar ^{[1
]}

机构：

[1] Visva Bharati Univ, Dept Chem, Lab Nat Prod & Organ Synth, Santini Ketan 731235, W Bengal, India

来源：

TETRAHEDRON LETTERS | 2012年 / 53卷 / 12期

关键词：

Bi(NO3)(3)center dot 5H(2)O; Heterocycles; Highly functionalized piperidines; One-pot synthesis; Tandem reaction; Multicomponent reaction; Room temperature; Environmentally benign; ANTI-MARKOVNIKOV HYDROAMINATION; ECONOMIC PASE SYNTHESIS; DIELS-ALDER REACTION; DIASTEREOSELECTIVE SYNTHESIS; CYCLIZATION REACTIONS; ASYMMETRIC-SYNTHESIS; CONCISE SYNTHESIS; IN-VITRO; DERIVATIVES; INHIBITORS;

D O I：

10.1016/j.tetlet.2012.01.042

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple, straightforward, and highly efficient diastereoselective multicomponent one-pot synthesis of a series of pharmaceutically interesting functionalized piperidine derivatives has been developed based on a low-cost and environmentally benign Bi(NO3)(3)center dot 5H(2)O catalyst via tandem reactions of 1,3-dicarbonyl compounds, aromatic aldehydes, and various amines in ethanol at room temperature. High atom-economy, good yields, eco-friendliness, and mild reaction conditions are some of the important features of this protocol. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：1479 / 1484

页数：6

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