Role of connexins and pannexins in cardiovascular physiology

被引：35

作者：

Meens, Merlijn J. ^{[1
,2
]}

Kwak, Brenda R. ^{[1
,2
]}

Duffy, Heather S. ^{[3
]}

机构：

[1] Univ Geneva, Dept Pathol & Immunol, CH-1211 Geneva 4, Switzerland

[2] Univ Geneva, Dept Med Specializat Cardiol, CH-1211 Geneva 4, Switzerland

[3] Creat Innovat Consulting, Ashland, MA 01721 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2015年 / 72卷 / 15期

基金：

瑞士国家科学基金会;

关键词：

Connexins; Pannexins; Gap junction channel; Hemichannel; Cardiovascular; Physiology; GAP-JUNCTION CHANNELS; VASCULAR ENDOTHELIAL-CELLS; RECEPTOR-DEFICIENT MICE; SMOOTH-MUSCLE-CELLS; C-SRC; CARDIAC MYOCYTES; HYPERPOLARIZING FACTOR; PROTEIN CONNEXIN-43; ZONULA OCCLUDENS-1; INTERCALATED DISC;

D O I：

10.1007/s00018-015-1959-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Connexins and pannexins form connexons, pannexons and membrane channels, which are critically involved in many aspects of cardiovascular physiology. For that reason, a vast number of studies have addressed the role of connexins and pannexins in the arterial and venous systems as well as in the heart. Moreover, a role for connexins in lymphatics has recently also been suggested. This review provides an overview of the current knowledge regarding the involvement of connexins and pannexins in cardiovascular physiology.

引用

页码：2779 / 2792

页数：14

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