Depressive symptoms in Parkinson's disease are related to decreased left hippocampal volume: correlation with the 15-item shortened version of the Geriatric Depression Scale

被引：28
作者：
Goto, Masami [1 ]
Kamagata, Koji [2 ]
Hatano, Taku [3 ]
Hattori, Nobutaka [3 ]
Abe, Osamu [4 ]
Aoki, Shigeki [2 ]
Hori, Masaaki [2 ]
Gomi, Tsutomu [1 ]
机构：
[1] Kitasato Univ, Sch Allied Hlth Sci, Sagamihara, Kanagawa, Japan
[2] Juntendo Univ, Dept Radiol, Tokyo, Japan
[3] Juntendo Univ, Dept Neurol, Tokyo, Japan
[4] Univ Tokyo Hosp, Dept Radiol, Tokyo, Japan
来源：
ACTA RADIOLOGICA | 2018年 / 59卷 / 03期
关键词：
Geriatric Depression Scale; hippocampus; Parkinson's disease; depression; voxel-based morphometry; VOXEL-BASED MORPHOMETRY; ATLAS-BASED METHOD; GRAY-MATTER VOLUME; ALZHEIMERS-DISEASE; AMYGDALA VOLUME; TEMPORAL-LOBE; INVENTORY; PROGRESSION; SCANNER; ONSET;
D O I：
10.1177/0284185117719100
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Background: The relationship between hippocampal and amygdaloid volumes and depression in patients with Parkinson's disease (PD) is a controversial issue. Purpose: To investigate the correlation between the 15-item shortened version of the Geriatric Depression Scale (GDS-15) and gray matter volume in PD. Material and Methods: In the present study, 46 participants with PD were scanned with 3T magnetic resonance imaging (MRI) to obtain three-dimensional (3D) T1-weighted (T1W) images. Neurologists specializing in movement disorders performed clinical evaluations of the participants (e.g. GDS-15, Mini-Mental State Examination, PD duration, age, sex). Statistical Parametric Mapping 8 software was used for image gray matter segmentation and for a correlation analysis between gray matter volume and GDS-15 score. Results: The results showed a significant negative correlation between GDS-15 score and left hippocampal volume, and between GDS-15 score and right parahippocampal gyrus volume. No significant positive correlations were found in the whole brain. Conclusion: The current results provide new evidence regarding the relationship between depression in PD and hippocampal volume.
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收藏
页码：341 / 345
页数：5
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