Early and Presenting Symptoms of Dementia with Lewy Bodies

被引：75

作者：

Auning, Eirik ^{[2
]}

Rongve, Arvid ^{[4
]}

Fladby, Tormod ^{[3
]}

Booij, Jan ^{[6
]}

Hortobagyi, Tibor ^{[7
,9
]}

Siepel, Francoise J. ^{[5
]}

Ballard, Clive ^{[8
]}

Aarsland, Dag ^{[1
,5
,10
]}

机构：

[1] Karolinska Inst, KI Alzheimer Dis Res Ctr, NVS Dept, SE-14186 Stockholm, Sweden

[2] Akershus Univ Hosp, Dept Geriatr Psychiat, Lorenskog, Norway

[3] Akershus Univ Hosp, Dept Neurol, Lorenskog, Norway

[4] Haugesund Hosp, Dept Psychiat, Haugesund, Norway

[5] Stavanger Univ Hosp, Dept Geriatr Psychiat, Psychiat Clin, Stavanger, Norway

[6] Univ Amsterdam, Acad Med Ctr, Dept Nucl Med, NL-1105 AZ Amsterdam, Netherlands

[7] Kings Coll London, Inst Psychiat, Dept Clin Neurosci, London WC2R 2LS, England

[8] Kings Coll London, Wolfson Ctr Age Related Dis, London WC2R 2LS, England

[9] Univ Debrecen, Inst Pathol, Dept Neuropathol, Debrecen, Hungary

[10] Univ Oslo, Oslo, Norway

来源：

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 2011年 / 32卷 / 03期

关键词：

Dementia with Lewy bodies; Alzheimer's disease dementia; Parkinsonism; Predementia; Carer report; PARKINSONS-DISEASE; ALZHEIMERS-DISEASE; AUTONOMIC FAILURE; DIAGNOSIS; DLB; PATHOLOGY; SURVIVAL; SPECT;

D O I：

10.1159/000333072

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Background/Aims: To explore the presenting and early symptoms of dementia with Lewy bodies (DLB). Method: Patients with mild dementia fulfilling diagnostic criteria for DLB (n = 61) and Alzheimer's disease (AD) (n = 109) were recruited from outpatient dementia clinics in western Norway. At diagnosis, caregivers were asked which symptom had been the presenting symptom of dementia. Results: Caregivers reported that memory impairment was the most common presenting symptom in DLB (57%), followed by visual hallucinations (44%), depression (34%), problem solving difficulties (33%), gait problems (28%), and tremor/stiffness (25%). In contrast, 99% of AD carers reported impaired memory as a presenting symptom, whereas visual hallucinations were a presenting symptom in 3% of the AD cases. Conclusion: DLB should be suspected in predementia cases with visual hallucinations. Copyright (C) 2011 S. Karger AG, Basel

引用

页码：202 / 208

页数：7

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