Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) -: Structural investigations on two different carrier systems

被引：0
作者：
Saupe, A
Wissing, SA
Lenk, A
Schmidt, C
Müller, RH
机构：
[1] Biotechnol & Qual Management, Dept Pharmaceut Technol, D-12169 Berlin, Germany
[2] Drug Delivery Serv GmbH, D-24119 Kronshagen, Germany
[3] Tech Univ Dresden, Dept Struct Phys, D-01069 Dresden, Germany
来源：
BIO-MEDICAL MATERIALS AND ENGINEERING | 2005年 / 15卷 / 05期
关键词：
SLN; NLC; physical stability; loading capacity; particulate character; scaling up feasibility;
D O I：
暂无
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Two different types of colloidal lipid particles are presented and compared as innovative carrier systems. Size distribution and storage stability of formulations produced by hot high pressure homogenisation in lab and medium scale production were investigated by laser diffractometry (LD) and photon correlation spectroscopy (PCS). Nanoparticles were characterised by their melting and recrystallisation behaviour recorded by differential scanning calorimetry (DSC). Electron microscope investigations were also carried out showing the particulate character of these carriers. Reasons for observed differences in loading capacity are discussed and possibilities for dermal application are described.
引用
收藏
页码：393 / 402
页数：10
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