The cloning of a human ABC gene (ABC3) mapping to chromosome 16p13.3

被引：45

作者：

Connors, TD ^{[1
]}

VanRaay, TJ ^{[1
]}

Petry, LR ^{[1
]}

Klinger, KW ^{[1
]}

Landes, GM ^{[1
]}

Burn, TC ^{[1
]}

机构：

[1] GENZYME CORP,GENET,DEPT HUMAN GENET,FRAMINGHAM,MA 01701

来源：

GENOMICS | 1997年 / 39卷 / 02期

关键词：

D O I：

10.1006/geno.1996.4500

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The ATP binding cassette (ABC) transporters, or traffic ATPases, constitute a large family of proteins responsible for the transport of a wide variety of substrates across cell membranes in both prokaryotic and eukaryotic cells. We describe a human ABC protein with regions of strong homology to the recently described murine ABC1 and ABC2 transporters. The gene for this novel protein, human ABC3, maps near the polycystic kidney disease type 1 (PKD1) gene on chromosome 16p13.3. The ABC3 gene is expressed at highest levels in lung compared to other tissues. (C) 1997 Academic Press

引用

页码：231 / 234

页数：4

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