L-myc genotypes in Hong Kong Chinese colorectal carcinoma patients

被引：0

作者：

Ko, JMY

Cheung, MHY

Wong, CM

Lau, KW

Tang, CMC

Kwan, MW

Lung, ML ^{[1
]}

机构：

[1] Hong Kong Univ Sci & Technol, Dept Biol, Kowloon, Peoples R China

[2] Tuen Mun Hosp, Dept Surg, Tuen Mun, Peoples R China

[3] Tuen Mun Hosp, Dept Pathol, Tuen Mun, Peoples R China

来源：

ONCOLOGY REPORTS | 1999年 / 6卷 / 02期

关键词：

L-myc; colorectal cancer;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

L-myc genotypes have been correlated with prognosis in different human tumors. Its role in colorectal carcinoma (CRC) is still unclear. This study aimed to assess the L-myc genotypes in 99 Hong Kong Chinese CRC patients by PCR-RFLP techniques. The results obtained were correlated with clinical, histological and pathological parameters and genetic alterations. The observed frequency of L-myc genotypes (LL:LS:SS) was 27:46:26. The ratio of S to L alleles was 0.51:0.49. Distribution of L-myc genotypes and alleles in Hong Kong Chinese CRC was similar to that of healthy Chinese and CRC patients of other ethnic origins. The homozygous SS genotype was significantly associated with Dukes' stages C versus B. Other parameters including sex, differentiation status and survival, and genetic alterations such as p53 and Ki-ras mutations and Dec LOH had no significant association with L-myc SS genotype.

引用

页码：441 / 444

页数：4