2-Hydroxy-4-isopropylbenzaldehyde, a potent partial tyrosinase inhibitor

被引：43

作者：

Nihei, K

Yamagiwa, Y

Kamikawa, T

Kubo, I ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Environm Sci Policy & Management, Berkeley, CA 94720 USA

[2] Kinki Univ, Fac Sci & Technol, Dept Chem, Higashiosaka, Osaka 5778502, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 03期

关键词：

mushroom tyrosinase; benzaldehydes; chamaecin; Vilsmeier reaction; partial mixed type inhibitor;

D O I：

10.1016/j.bmcl.2003.11.033

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Chamaecin (2-hydroxy-4-isopropylbenzaldehyde) was synthesized and tested for its tyrosinase inhibitory activity. It partially inhibits the oxidation Of L-3,4-dihydroxyphenylalanine (L-DOPA) catalyzed by mushroom tyrosinase with an IC50 of 2.3 muM. The inhibition kinetics analyzed by Dixon plots found that chamaecin is a mixed type inhibitor. This inhibition may come in part from its ability to form a Schiff base with a primary amino group in the enzyme. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：681 / 683

页数：3

共 21 条

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