The neuropeptide cyclase-activating pituitary adenylate polypeptide and islet function

被引：58

作者：

Filipsson, K ^{[1
]}

Kvist-Reimer, M ^{[1
]}

Ahrén, B ^{[1
]}

机构：

[1] Lund Univ, Dept Med, BMC, SE-22184 Lund, Sweden

来源：

DIABETES | 2001年 / 50卷 / 09期

关键词：

D O I：

10.2337/diabetes.50.9.1959

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) is ubiquitously distributed in both the central and peripheral nervous systems and exerts a variety of effects. PACAP is a neuropeptide in pancreatic islets, where it has been suggested as a parasympathetic and sensory neurotransmitter. PACAP stimulates insulin secretion in a glucose-dependent manner, by an effect executed mainly through augmenting the formation of cAMP and stimulating the uptake of calcium. Accumulating evidence in animal studies points to a physiological importance of PACAP in the regulation of the insulin response to feeding. This review summarizes the current knowledge of islet actions and mechanisms and the function of PACAP.

引用

页码：1959 / 1969

页数：11

共 93 条

[1] Signaling mechanisms underlying the insulinotropic effect of pituitary adenylate cyclase-activating polypeptide in HIT-T15 cells [J].