Active sampling and decision making in Drosophila chemotaxis

被引:171
作者
Gomez-Marin, Alex [1 ,2 ]
Stephens, Greg J. [3 ,4 ]
Louis, Matthieu [1 ,2 ]
机构
[1] CRG, EMBL CRG Syst Biol Unit, Barcelona 08003, Spain
[2] UPF, Barcelona 08003, Spain
[3] Princeton Univ, Joseph Henry Labs Phys, Princeton, NJ 08544 USA
[4] Princeton Univ, Lewis Sigler Inst Integrat Genom, Princeton, NJ 08544 USA
基金
美国国家科学基金会; 美国国家卫生研究院;
关键词
BEHAVIOR; LOBSTER; OSMOTROPOTAXIS; ORIENTATION; PERCEPTION; MECHANISMS; TRACKING; SYSTEM; SNIFF; LARVA;
D O I
10.1038/ncomms1455
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The ability to respond to chemical stimuli is fundamental to the survival of motile organisms, but the strategies underlying odour tracking remain poorly understood. Here we show that chemotaxis in Drosophila melanogaster larvae is an active sampling process analogous to sniffing in vertebrates. Combining computer-vision algorithms with reconstructed olfactory environments, we establish that larvae orient in odour gradients through a sequential organization of stereotypical behaviours, including runs, stops, lateral head casts and directed turns. Negative gradients, integrated during runs, control the timing of turns. Positive gradients detected through high-amplitude head casts determine the direction of individual turns. By genetically manipulating the peripheral olfactory circuit, we examine how orientation adapts to losses and gains of function in olfactory input. Our findings suggest that larval chemotaxis represents an intermediate navigation strategy between the biased random walks of Escherichia Coli and the stereo-olfaction observed in rats and humans.
引用
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页数:10
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