Oxidative stress and Nrf2 in the pathophysiology of diabetic neuropathy: Old perspective with a new angle

被引:123
作者
Negi, Geeta [1 ]
Kumar, Ashutosh [1 ]
Joshi, Rayanta P. [1 ]
Sharma, Shyam S. [1 ]
机构
[1] NIPER, Mol Neuropharmacol Lab, Dept Pharmacol & Toxicol, SAS Nagar, Mohali 160062, Punjab, India
关键词
Diabetic neuropathy; Oxidative stress; Nrf2; NF-KAPPA-B; TRANSCRIPTION FACTOR NRF2; RETINAL GANGLION-CELLS; ANTIOXIDANT RESPONSE; NITROSATIVE STRESS; ENDOTHELIAL-CELLS; ALDOSE REDUCTASE; MOLECULAR-MECHANISMS; SENSORY NEURONS; UP-REGULATION;
D O I
10.1016/j.bbrc.2011.03.087
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Long-standing diabetes and complications thereof particularly, neuropathy stands for one of the major causes of morbidity across the globe. It is postulated that excessive production of reactive oxygen species is a key component in the development and progression of diabetic neuropathy. Oxidative damage is the most common concluding pathway for various pathogenetic mechanisms of neuronal injury in diabetic neuropathy. However despite optimistic preclinical data, it is still very ambiguous that why antioxidants have failed to demonstrate significant neuroprotection in humans. A growing body of evidences now suggests that strategies utilizing a more targeted approach like focusing on Nrf2 (a transcription factor modulating oxidative stress) may provide an enthralling avenue to optimize neuroprotection in diabetes and diabetic neuropathy. This review presents an emerging concept of Nrf2 in diabetic neuropathy; thus looking forward to newer strategies for combating the oxidant induced damage. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码:1 / 5
页数:5
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