Pd(II)-Catalyzed Ortho Arylation of 6-Arylpurines with Aryl Iodides via Purine-Directed C-H Activation: A New Strategy for Modification of 6-Arylpurine Derivatives

被引：58

作者：

Guo, Hai-Ming ^{[1
]}

Jiang, Li-Li ^{[1
]}

Niu, Hong-Ying ^{[2
]}

Rao, Wei-Hao ^{[1
]}

Liang, Lei ^{[1
]}

Mao, Run-Ze ^{[1
]}

Li, De-Yang ^{[1
]}

Qu, Gui-Rong ^{[1
]}

机构：

[1] Henan Normal Univ, Coll Chem & Environm Sci, Key Lab Green Chem Media & React, Minist Educ, Xinxiang 453007, Peoples R China

[2] Henan Inst Sci & Technol, Sch Chem & Chem Engn, Xinxiang 453003, Peoples R China

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 08期

关键词：

CROSS-COUPLING REACTIONS; CATALYZED DIRECT ARYLATION; BOND ACTIVATION; SIMPLE ARENES; CYTOSTATIC ACTIVITY; SODIUM PERSULFATE; ORGANIC HALIDES; N-OXIDES; PALLADIUM; NUCLEOSIDES;

D O I：

10.1021/ol200405w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Purine is utilized as a new directing group for the Pd-catalyzed monoarylation of 6-arylpurines with simple aryl iodides via C H bond activation in good yields, providing a complementary tool for the modification of 6-arylpurines (nucleosides). Most importantly, purine can be used as a building block for nucleoside derivatives, and the use of purine as a directing group helps avoid additional synthetic steps.

引用

页码：2008 / 2011

页数：4

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