Micelle-like nanoparticles of PLA-PEG-PLA triblock copolymer as chemotherapeutic carrier

被引：106
作者：
Venkatraman, SS
Jie, P
Min, F
Freddy, BYC
Leong-Huat, G
机构：
[1] Nanyang Technol Univ, Sch Mat Sci & Engn, Singapore 639798, Singapore
[2] Hong Kong Polytech Univ, Dept Appl Biol & Chem Biol, Kowloon, Hong Kong, Peoples R China
[3] Nanyang Technol Univ, Natl Inst Educ, Singapore 637616, Singapore
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2005年 / 298卷 / 01期
关键词：
PLA; PEG; drug carrier; 5-FU; paclitaxel;
D O I：
10.1016/j.ijpharm.2005.03.023
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Triblock copolymer PLA-PEG-PLA were synthesized using ring opening polymerization with different LA/EG ratio. Micellar aggregates were prepared from these block copolymers and characterized. The degradation characteristics of selected copolymers were assessed in both micellar and film forms. Surface segregation of PEG was also quantified as a function of copolymer composition. Anti-cancer drugs 5-FU and paclitaxel were loaded into the micellar nanospheres with good efficiency. The drug release profile showed good control over the release of paclitaxel from these polymers. (c) 2005 Elsevier B.V. All rights reserved.
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收藏
页码：219 / 232
页数：14
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