Preliminary in vitro evaluation of the anti-proliferative activity of guanylhydrazone derivatives

被引：12

作者：

Franca, Paulo H. B. ^{[2
]}

Da Silva-Junior, Edeildo F. ^{[2
]}

Aquino, Pedro G. V. ^{[1
]}

Santana, Antonio E. G. ^{[1
]}

Ferro, Jamylle N. S. ^{[3
]}

Barreto, Emiliano De Oliveira ^{[3
]}

Pessoa, Claudia Do O. ^{[4
]}

Meira, Assuero Silva ^{[4
]}

De Aquino, Thiago M. ^{[2
]}

Alexandre-Moreira, Magna S. ^{[5
]}

Schmitt, Martine ^{[6
]}

De Araujo-Junior, Joao X. ^{[2
]}

机构：

[1] Univ Fed Alagoas, Inst Chem & Biotechnol, Nat Resources Res Lab, Maceio, Brazil

[2] Univ Fed Alagoas, Sch Nursing & Pharm, Med Chem Lab, Maceio, Brazil

[3] Univ Fed Alagoas, Cell Biol Lab, Biol & Hlth Sci, Maceio, Brazil

[4] Univ Fed Ceara, Dept Physiol & Pharmacol, Expt Oncol Lab, Fortaleza, Ceara, Brazil

[5] Univ Fed Alagoas, Inst Biol & Hlth Sci, Lab Pharmacol & Immun, Maceio, Brazil

[6] Univ Strasbourg, Lab Innovat Therapeut, Fac Pharm, Illkirck, France

来源：

ACTA PHARMACEUTICA | 2016年 / 66卷 / 01期

关键词：

guanylhydrazone; cytotoxic effect; synthesis; MTT assay; INHIBITORS; RECEPTOR;

D O I：

10.1515/acph-2016-0015

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Guanylhydrazones have shown promising antitumor activity in preclinical tumor models in several studies. In this study, we aimed at evaluating the cytotoxic effect of a series of synthetic guanylhydrazones. Different human tumor cell lines, by including HCT-8 (colon carcinoma), MDA-MB-435 (melanoma) and SF-295 (glioblastoma) were continuous exposed to guanylhydrazone derivatives for 72 hours and growth inhibition of tumor cell lines and macrophages J774 was measured using tetrazolium salt (MTT) assay. Compounds 7, 11, 16 and 17 showed strong cytotoxic activity with IC50 values lower than 10 mu mol L-1 against four tumor cell lines. Among them, 7 was less toxic to non-tumor cells. Finally, obtained data suggest that guanylhydrazones may be regarded as potential lead compounds for the design of novel anticancer agents.

引用

页码：129 / 137

页数：9

共 50 条

[21] The anti-proliferative and anti-androgenic activity of different pomegranate accessions
Orgil, Ola
Spector, Limor
Holland, Down
Mahajna, Jamal
Amir, Rachel
JOURNAL OF FUNCTIONAL FOODS, 2016, 26 : 517 - 528
[22] Novel coumarin-6-sulfonamides as apoptotic anti-proliferative agents: synthesis, in vitro biological evaluation, and QSAR studies
Sabt, Ahmed
Abdelhafez, Omaima M.
El-Haggar, Radwan S.
Madkour, Hassan M. F.
Eldehna, Wagdy M.
El-Khrisy, Ezz El-Din A. M.
Abdel-Rahman, Mohamed A.
Rashed, Laila A.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2018, 33 (01) : 1095 - 1107
[23] Synthesis and Anti-Proliferative Activity of Sulfanyltriazolylnaphthalenols and Sulfanyltriazolylnaphthalene-1,4-diones
Chaaban, Ibrahim
El Khawass, El Sayeda M.
Abd El Razik, Heba A.
El Salamouni, Nehad S.
Redondo-Horcajo, Mariano
Barasoain, Isabel
Fernando Diaz, Jose
Yli-Kauhaluoma, Jari
Moreira, Vania M.
ARCHIV DER PHARMAZIE, 2016, 349 (09) : 749 - 761
[24] 3-Arylcoumarin Derivatives Manifest Anti-proliferative Activity through Hsp90 Inhibition
Zhao, Huiping
Yan, Bin
Peterson, Laura B.
Blagg, Brian S. J.
ACS MEDICINAL CHEMISTRY LETTERS, 2012, 3 (04): : 327 - 331
[25] Synthesis of a new series of pyrimidine derivatives: exploration of anti-proliferative activity on EAT cells and molecular docking
Senthilkumar, N.
Ravichandran, Y. Dominic
Kumar, K. M.
Ramaiah, Sudha
RESEARCH ON CHEMICAL INTERMEDIATES, 2016, 42 (02) : 1295 - 1313
[26] Design, synthesis and anti-proliferative studies of a novel series of indirubin derivatives
Wang, Tian Cai
Wei, Ju Zhi
Guo, Chuan Sheng
Zhang, Hui Bin
Fan, Hou Xing
CHINESE CHEMICAL LETTERS, 2010, 21 (12) : 1407 - 1410
[27] Synthesis and anti-proliferative activity of fluoro-substituted chalcones
Burmaoglu, Serdar
Algul, Oztekin
Anil, Derya Aktas
Gobek, Arzu
Duran, Gulay Gulbol
Ersan, Ronak Haj
Duran, Nizami
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 26 (13) : 3172 - 3176
[28] Anti-proliferative, structure-activity relationship of pyridinylchalcones and chromanones
Dayakar, Cherupally
Suman, Pathi
Rajkumar, Kommera
Murthy, Thampunuri Ramalinga
Kalivendi, Shasi Vardhan
Raju, Bhimapaka China
MEDICINAL CHEMISTRY RESEARCH, 2018, 27 (01) : 80 - 94
[29] Fluorescent schweinfurthin B and F analogs with anti-proliferative activity
Topczewski, Joseph J.
Kuder, Craig H.
Neighbors, Jeffrey D.
Hohl, Raymond J.
Wiemer, David F.
BIOORGANIC & MEDICINAL CHEMISTRY, 2010, 18 (18) : 6734 - 6741
[30] In vitro anti-proliferative and apoptotic effects of ethanolic extract of Cissus quadrangularis
Arshad, M.
Siddiqui, Sahabjada
Ali, Daoud
CARYOLOGIA, 2016, 69 (02) : 128 - 132

← 1 2 3 4 5 →