(±)-Uncarilins A and B, Dimeric Isoechinulin-Type Alkaloids from Uncaria rhynchophylla

被引：42
作者：
Geng, Chang-An
Huang, Xiao-Yan
Ma, Yun-Bao
Hou, Bo
Li, Tian-Ze
Zhang, Xue-Mei
Chen, Ji-Jun [1 ]
机构：
[1] Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Peoples R China
来源：
JOURNAL OF NATURAL PRODUCTS | 2017年 / 80卷 / 04期
基金：
中国国家自然科学基金;
关键词：
MELATONIN RECEPTORS; 2,5-DIKETOPIPERAZINES; DERIVATIVES; ANTAGONISTS; CHEMISTRY; MT1;
D O I：
10.1021/acs.jnatprod.6b00938
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
(+/-)-Uncarilins A and B (1a/1b and 2a/2b), two. pairs of-unusual dirrieric isoechinulin-type enantiomers with a symmetric four-membered core, were isolated from Uncaria rhynchophylla driven by LCMS-IT-TOF analyses. Their structures were elucidated by extensive 1D and 2D NMR spectra, X-ray diffraction, and ECD Spectrbscopic data. (-)-Uncarilin B (2a) showed activities on MT1 and MT2 receptors with agonistic rates of 11.26% and 52.44% at a concentration of 0.25 mM.
引用
收藏
页码：959 / 964
页数：6
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