The trypanosome flagellar pocket

被引：192

作者：

Field, Mark C. ^{[1
]}

Carrington, Mark ^{[2
]}

机构：

[1] Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England

[2] Univ Cambridge, Dept Biochem, Cambridge CB2 1QW, England

来源：

NATURE REVIEWS MICROBIOLOGY | 2009年 / 7卷 / 11期

基金：

英国惠康基金;

关键词：

VARIANT SURFACE GLYCOPROTEIN; POLY-N-ACETYLLACTOSAMINE; SLEEPING-SICKNESS; TRANSFERRIN RECEPTOR; AFRICAN TRYPANOSOME; ENDOCYTIC FUNCTIONS; ANTIGENIC VARIATION; BRUCEI-RHODESIENSE; ANCHORED PROTEIN; SINGLE DYNAMIN;

D O I：

10.1038/nrmicro2221

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Trypanosomes are important disease agents and excellent models for the study of evolutionary cell biology. The trypanosome flagellar pocket is a small invagination of the plasma membrane where the flagellum exits the cytoplasm and participates in many cellular processes. It is the only site of exocytosis and endocytosis and part of a multiorganelle complex that is involved in cell polarity and cell division. Several flagellar pocket-associated proteins have been identified and found to contribute to trafficking and virulence. In this Review we discuss the contribution of the flagellar pocket to protein trafficking, immune evasion and other processes.

引用

页码：775 / 786

页数：12

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