Recent developments in cancer research: Expectations for a new remedy

被引：11

作者：

Ando, Koji ^{[1
]}

Hu, Qingjiang ^{[1
]}

Kasagi, Yuta ^{[1
]}

Oki, Eiji ^{[1
]}

Mori, Masaki ^{[1
]}

机构：

[1] Kyushu Univ, Dept Surg & Sci, Fukuoka, Japan

来源：

ANNALS OF GASTROENTEROLOGICAL SURGERY | 2021年 / 5卷 / 04期

关键词：

exosomes; immunotherapy; microbiome; organoid;

D O I：

10.1002/ags3.12440

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Cancer research has made remarkable progress and new discoveries are beginning to be made. For example, the discovery of immune checkpoint inhibition mechanisms in cancer cells has led to the development of immune checkpoint inhibitors that have benefited many cancer patients. In this review, we will introduce and describe the latest novel areas of cancer research: exosomes, microbiome, immunotherapy. and organoids. Exosomes research will lead to further understanding of the mechanisms governing cancer proliferation, invasion, and metastasis, as well as the development of cancer detection and therapeutic methods. Microbiome are important in understanding the disease. Immunotherapy is the fourth treatment in cancer therapy. Organoid biology will further develop with a goal of translating the research into personalized therapy. These research areas may result in the creation of new cancer treatments in the future.

引用

页码：419 / 426

页数：8

共 67 条

[1] Human Gut Microbiome and Risk for Colorectal Cancer [J].

Ahn, Jiyoung ;

Sinha, Rashmi ;

Pei, Zhiheng ;

Dominianni, Christine ;

Wu, Jing ;

Shi, Jianxin ;

Goedert, James J. ;

Hayes, Richard B. ;

Yang, Liying .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2013, 105 (24) :1907-1911

[2] The SIRP family of receptors and immune regulation [J].

Barclay, AN ;

Brown, MH .

NATURE REVIEWS IMMUNOLOGY, 2006, 6 (06) :457-464

[3] Organoid Models of Human and Mouse Ductal Pancreatic Cancer [J].

Boj, Sylvia F. ;

Hwang, Chang-Il ;

Baker, Lindsey A. ;

Chio, Iok In Christine ;

Engle, Dannielle D. ;

Corbo, Vincenzo ;

Jager, Myrthe ;

Ponz-Sarvise, Mariano ;

Tiriac, Herve ;

Spector, Mona S. ;

Gracanin, Ana ;

Oni, Tobiloba ;

Yu, Kenneth H. ;

van Boxtel, Ruben ;

Huch, Meritxell ;

Rivera, Keith D. ;

Wilson, John P. ;

Feigin, Michael E. ;

Oehlund, Daniel ;

Handly-Santana, Abram ;

Ardito-Abraham, Christine M. ;

Ludwig, Michael ;

Elyada, Ela ;

Alagesan, Brinda ;

Biffi, Giulia ;

Yordanov, Georgi N. ;

Delcuze, Bethany ;

Creighton, Brianna ;

Wright, Kevin ;

Park, Youngkyu ;

Morsink, Folkert H. M. ;

Molenaar, I. Quintus ;

Rinkes, Inne H. Borel ;

Cuppen, Edwin ;

Hao, Yuan ;

Jin, Ying ;

Nijman, Isaac J. ;

Iacobuzio-Donahue, Christine ;

Leach, Steven D. ;

Pappin, Darryl J. ;

Hammell, Molly ;

Klimstra, David S. ;

Basturk, Olca ;

Hruban, Ralph H. ;

Offerhaus, George Johan ;

Vries, Robert G. J. ;

Clevers, Hans ;

Tuveson, David A. .

CELL, 2015, 160 (1-2) :324-338

[4] Exosomes: Isolation, Analysis, and Applications in Cancer Detection and Therapy [J].

Bu, Hongchang ;

He, Dinggeng ;

He, Xiaoxiao ;

Wang, Kemin .

CHEMBIOCHEM, 2019, 20 (04) :451-461

[5] Exosomes of glioma cells deliver miR-148a to promote proliferation and metastasis of glioblastoma via targeting CADM1 [J].

Cai, Qian ;

Zhu, Anding ;

Gong, Li .

BULLETIN DU CANCER, 2018, 105 (7-8) :643-651

[6] Impact of demographics on human gut microbial diversity in a US Midwest population [J].

Chen, Jun ;

Ryu, Euijung ;

Hathcock, Matthew ;

Ballman, Karla ;

Chia, Nicholas ;

Olson, Janet E. ;

Nelson, Heidi .

PEERJ, 2016, 4

[7] Liquid biopsy: monitoring cancer-genetics in the blood [J].

Crowley, Emily ;

Di Nicolantonio, Federica ;

Loupakis, Fotios ;

Bardelli, Alberto .

NATURE REVIEWS CLINICAL ONCOLOGY, 2013, 10 (08) :472-484

[8] The role of the gut microbiome in the healthy adult status [J].

D'Argenio, Valeria ;

Salvatore, Francesco .

CLINICA CHIMICA ACTA, 2015, 451 :97-102

[9] The human microbiome in evolution [J].

Davenport, Emily R. ;

Sanders, Jon G. ;

Song, Se Jin ;

Amato, Katherine R. ;

Clark, Andrew G. ;

Knight, Rob .

BMC BIOLOGY, 2017, 15

[10] A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis [J].

Fujii, Masayuki ;

Shimokawa, Mariko ;

Date, Shoichi ;

Takano, Ai ;

Matano, Mami ;

Nanki, Kosaku ;

Ohta, Yuki ;

Toshimitsu, Kohta ;

Nakazato, Yoshihiro ;

Kawasaki, Kenta ;

Uraoka, Toshio ;

Watanabe, Toshiaki ;

Kanai, Takanori ;

Sato, Toshiro .

CELL STEM CELL, 2016, 18 (06) :827-838

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