Synthesis of 6- and 7-(1,2,3-trihydroxy-1,2-O-isopropylidenepropyl)pteridines and deoxygenation of their 3′-hydroxy groups

被引：5

作者：

Hanaya, Tadashi ^{[1
]}

Takayama, Daisuke ^{[1
]}

Yamamoto, Hiroshi ^{[1
]}

机构：

[1] Okayama Univ, Fac Sci, Dept Chem, Okayama 7008530, Japan

来源：

HETEROCYCLES | 2006年 / 70卷

关键词：

pteridine-ring formation; L-threo-pentos-2-ulose; 1,3-dimethyllumazine; deoxygenation; L-arabinopyranoside; PTERIN CHEMISTRY; BIOPTERIN; DERIVATIVES; PTERIDINES; NEOPTERIN; SPECTRA;

D O I：

10.3987/COM-06-S(W)33

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of 3,4-O-isopropylidene-L-threo-pentos-2-ulose (7) with 5,6-diamino-1,3-dimethyluracil (8) afforded 1,3-dimethyl-6-[(1R,2S)-1,2,3-trihydroxy-1,2-O-isopropylidenepropyl]lumazine (9a) and its 7-substituted isomer (9b). Deoxygenation of 3'-hydroxy groups of 9a,b was investigated in connection with a practical transformation of neopterin into biopterin.

引用

页码：355 / +

页数：12

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