Maternal age and oral clefts: A reappraisal

被引：33

作者：

Vieira, AR

Orioli, IM

Murray, JC

机构：

[1] Univ Iowa, Dept Pediat, Iowa City, IA 52242 USA

[2] Univ Iowa, Dept Biol Sci, Iowa City, IA 52242 USA

[3] Univ Iowa, Gen PhD Program, Iowa City, IA 52242 USA

[4] Univ Fed Rio de Janeiro, Dept Genet, Latin Amer Collaborat Study Congenital Malformat, BR-21941 Rio De Janeiro, Brazil

来源：

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS | 2002年 / 94卷 / 05期

关键词：

D O I：

10.1067/moe.2002.128875

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Objective. The aim of the study was to test the hypothesis that increased maternal age is associated with a higher risk of having a child with oral clefts. Study design. A meta-analysis of 8 population-based studies with information regarding live birth and oral clefts was performed. Results. No association between increased maternal age and isolated oral clefts was found. Conclusion. Oral clefts occurrence is not correlated with increasing maternal age, and inclusion of data mixing isolated and syndromic cases can confound the analysis and must be avoided.

引用

页码：530 / 535

页数：6

共 40 条

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