Unique insula subregion resting-state functional connectivity with amygdala complexes in posttraumatic stress disorder and its dissociative subtype

被引：95

作者：

Nicholson, Andrew A. ^{[1
]}

Sapru, Iman ^{[1
]}

Densmore, Maria ^{[6
]}

Frewen, Paul A. ^{[1
,2
]}

Neufeld, Richard W. J. ^{[1
,2
,3
]}

Theberge, Jean ^{[3
,4
,5
,6
,7
]}

McKinnon, Margaret C. ^{[8
,9
,10
]}

Lanius, Ruth A. ^{[1
,3
,6
]}

机构：

[1] Univ Western Ontario, Dept Neurosci, London, ON, Canada

[2] Univ Western Ontario, Dept Psychol, London, ON, Canada

[3] Univ Western Ontario, Dept Psychiat, London, ON N6A 3K7, Canada

[4] Univ Western Ontario, Dept Med Imaging, London, ON, Canada

[5] Univ Western Ontario, Dept Medial Biophys, London, ON, Canada

[6] Lawson Hlth Res Inst, Imaging, London, ON, Canada

[7] St Josephs Healthcare, Dept Diagnost Imaging, London, ON, Canada

[8] St Josephs Healthcare, Mood Disorders Program, Hamilton, ON, Canada

[9] St Josephs Healthcare, Clin Neuropsychol Serv, Hamilton, ON, Canada

[10] McMaster Univ, Dept Psychiat & Behav Neurosci, Hamilton, ON, Canada

来源：

PSYCHIATRY RESEARCH-NEUROIMAGING | 2016年 / 250卷

基金：

加拿大健康研究院;

关键词：

PTSD; fMRI; Insular cortex; Basolateral amygdala; STRUCTURAL CONNECTIVITY; ANTERIOR INSULA; PTSD; FMRI; NETWORKS; INHIBITION; RESPONSES; SYMPTOMS; SYSTEMS; CORTEX;

D O I：

10.1016/j.pscychresns.2016.02.002

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The insula and amygdala are implicated in the pathophysiology of posttraumatic stress disorder (PTSD), where both have been shown to be hyper/hypoactive in non-dissociative (PTSD - DS) and dissociative subtype (PTSD+DS) PTSD patients, respectively, during symptom provocation. However, the functional connectivity between individual insula subregions and the amygdala has not been investigated in persons with PTSD, with or without the dissociative subtype. We examined insula subregion (anterior, mid, and posterior) functional connectivity with the bilateral amygdala using a region-of-interest seed-based approach via PickAtlas and SPM8. Resting-state fMRI was conducted with (n = 61) PTSD patients (n = 44 PTSD DS; n = 17 PTSD + DS), and (n =40) age-matched healthy controls. When compared to controls, the PTSD DS group displayed increased insula connectivity (bilateral anterior, bilateral mid, and left posterior) to basolateral amygdala clusters in both hemispheres, and the PTSD+DS group displayed increased insula connectivity (bilateral anterior, left mid, and left posterior) to the left basolateral amygdala complex. Moreover, as compared to PTSD DS, increased insula subregion connectivity (bilateral anterior, left mid, and right posterior) to the left basolateral amygdala was found in PTSD+DS. Depersonalization/derealization symptoms and PTSD symptom severity correlated with insula subregion connectivity to the basolateral amygdala within PTSD patients. This study is an important first step in elucidating patterns of neural connectivity associated with unique symptoms of arousal/interoception, emotional processing, and awareness of bodily states, in PTSD and its dissociative subtype. (c) 2016 Elsevier Ireland Ltd. All rights reserved.

引用

页码：61 / 72

页数：12

共 56 条

[1] Abnormal functional architecture of amygdala-centered networks in adolescent posttraumatic stress disorder [J].

Aghajani, Moji ;

Veer, Ilya M. ;

van Hoof, Marie-Jose ;

Rombouts, Serge A. R. B. ;

van der Wee, Nic J. ;

Vermeiren, Robert R. J. M. .

HUMAN BRAIN MAPPING, 2016, 37 (03) :1120-1135

[2]

[Anonymous], 1997, USERS GUIDE STRUCTUR

[3]

[Anonymous], 2015, EUROPEAN J PSYCHOTRA, DOI DOI 10.3402/EJPT.V6.27905LANIUS

[4] Executive function and PTSD: Disengaging from trauma [J].

Aupperle, Robin L. ;

Melrose, Andrew J. ;

Stein, Murray B. ;

Paulus, Martin P. .

NEUROPHARMACOLOGY, 2012, 62 (02) :686-694

[5] Resting-State Functional and Structural Connectivity Within an Insula-Amygdala Route Specifically Index State and Trait Anxiety [J].

Baur, Volker ;

Haenggi, Juergen ;

Langer, Nicolas ;

Jaencke, Lutz .

BIOLOGICAL PSYCHIATRY, 2013, 73 (01) :85-92

[6] Screening for major depression disorders in medical inpatients with the Beck Depression Inventory for Primary Care [J].

Beck, AT ;

Guth, D ;

Steer, RA ;

Ball, R .

BEHAVIOUR RESEARCH AND THERAPY, 1997, 35 (08) :785-791

[7] Development and validation of a brief screening version of the Childhood Trauma Questionnaire [J].

Bernstein, DP ;

Stein, JA ;

Newcomb, MD ;

Walker, E ;

Pogge, D ;

Ahluvalia, T ;

Stokes, J ;

Handelsman, L ;

Medrano, M ;

Desmond, D ;

Zule, W .

CHILD ABUSE & NEGLECT, 2003, 27 (02) :169-190

[8] fMRI in the presence of task-correlated breathing variations [J].

Birn, Rasmus M. ;

Murphy, Kevin ;

Handwerker, Daniel. A. ;

Bandettini, Peter A. .

NEUROIMAGE, 2009, 47 (03) :1092-1104

[9] THE DEVELOPMENT OF A CLINICIAN-ADMINISTERED PTSD SCALE [J].

BLAKE, DD ;

WEATHERS, FW ;

NAGY, LM ;

KALOUPEK, DG ;

GUSMAN, FD ;

CHARNEY, DS ;

KEANE, TM .

JOURNAL OF TRAUMATIC STRESS, 1995, 8 (01) :75-90

[10] Is dissociation a multidimensional construct? Data from the Multiscale Dissociation Inventory [J].

Briere, J ;

Weathers, FW ;

Runtz, M .

JOURNAL OF TRAUMATIC STRESS, 2005, 18 (03) :221-231

← 1 2 3 4 5 6 →