Increased Lacrimal Fluid Level of HMGB1 in Vernal Keratoconjunctivitis

被引：4

作者：

Caputo, Roberto ^{[1
]}

Pasti, Mattia ^{[1
]}

de Libero, Cinzia ^{[2
]}

Mori, Francesca ^{[2
]}

Barni, Simona ^{[2
]}

Danti, Gioia ^{[1
]}

Buonvicino, Daniela ^{[3
]}

Urru, Matteo ^{[3
]}

Chiarugi, Alberto ^{[3
]}

Pucci, Neri ^{[2
]}

机构：

[1] AOU Meyer, Dept Pediat Ophthalmol, Florence, Italy

[2] AOU Meyer, Dept Allergol, Florence, Italy

[3] Univ Firenze, Clin Pharmacol Sect, Dept Hlth Sci, Florence, Italy

来源：

OCULAR IMMUNOLOGY AND INFLAMMATION | 2019年 / 27卷 / 05期

关键词：

Vernal keratoconjunctivitis; HMGB1; allergy; PATHOGENESIS; PROTEIN;

D O I：

10.1080/09273948.2018.1467465

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: The aim of the present prospective study was to evaluate the lacrimal fluid concentration of HMGB1 in young patients affected by Vernal Keratoconjunctivitis (VKC) compared to a control group of healthy subjects of same age. Methods: Tear fluids was collected in a group of VKC patients and compared to a control group of healthy subjects. HMGB1 concentration was measured using the HMGB1 ELISA II test both in VCK and control subjects. Results: The mean concentration of HMGB1 in tear fluids of 45 VKC patients was 0,977 +/- 0,72 ng/ml whereas in the control group was 0,24 +/- 0,25 ng/ml and the difference was statistically significant (p = 0,000106) Conclusion: The concentration of HMGB1 in VCK patients was found to be significantly increased, suggesting a possible role of this protein in the inflammatory mechanism of VKC.

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收藏

页码：808 / 812

页数：5

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