Prospects for the future of prostate cancer vaccines

被引：8

作者：

Madan, Ravi A. ^{[1
]}

Gulley, James L. ^{[1
]}

机构：

[1] NCI, Genitourinary Malignancies Branch, Bethesda, MD 20892 USA

来源：

EXPERT REVIEW OF VACCINES | 2016年 / 15卷 / 03期

关键词：

combination therapy; therapeutic cancer vaccines; Vaccines; immune combinations; prostate cancer; CASTRATION; IMMUNOTHERAPY; ABIRATERONE; ANTAGONIST; IPILIMUMAB; THERAPY; CELLS; MEN;

D O I：

10.1586/14760584.2015.1118348

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cancer therapy is undergoing a revolution fueled by clinical data demonstrating that the immune system has significant anti-tumor capability. Although the main focus of this revolution currently rests upon immune checkpoint inhibitors in diseases such as melanoma, lung and bladder cancer, it was actually a therapeutic cancer vaccine in prostate cancer that provided the first data demonstrating that a modern immunotherapy, beyond cytokines, could enhance clinical outcomes. As immunotherapy is poised to take center stage among cancer therapies, the role of cancer vaccines remains somewhat undefined in prostate cancer, though emerging data suggest that vaccines could play a crucial therapeutic role.

引用

页码：271 / 274

页数：4

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