Differential expression profiles and functional analysis of circular RNAs in children with fulminant myocarditis

被引：23
作者：
Zhang, Li [1 ]
Han, Bo [1 ]
Wang, Jing [1 ]
Liu, Qingqing [1 ]
Kong, Yaru [1 ]
Jiang, Diandong [1 ]
Jia, Hailin [1 ]
机构：
[1] Shandong Univ, Dept Pediat Cardiol, Shandong Prov Hosp, 324 Jingwuweiqi Rd, Jinan 250021, Shandong, Peoples R China
来源：
EPIGENOMICS | 2019年 / 11卷 / 10期
基金：
中国国家自然科学基金;
关键词：
circular RNA; fulminant myocarditis; functional analysis; hsa_circ_0071542; microarray; CARDIOMYOPATHY; PROGRESSION; PATHWAY; MODEL;
D O I：
10.2217/epi-2019-0101
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Aim: To assess differential expression profiles of circular RNAs (circRNAs) and explore their possible functions in children with fulminant myocarditis. Materials & methods: circRNA microarray experiments were carried out for determining differential expression profiles of circRNAs in three children with fulminant myocarditis and three healthy volunteers. Functional analysis and circRNA-miRNA-mRNA interaction network building were conducted to study biological functions. Results: This work identified 2281 upregulated and 892 downregulated circRNAs. Further assessment confirmed hsa_circ_0071542 upregulation (2.5-fold) in fulminant myocarditis. Functional analysis demonstrated the differentially expressed circRNAs mainly contributed to inflammation and immunity. Conclusion: circRNAs might have substantial roles in pediatric fulminant myocarditis, and hsa_circ_0071542 could serve as a promising biomarker.
引用
收藏
页码：1129 / 1142
页数：14
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