共 153 条
Postburn Hypermetabolism: Past, Present, and Future
被引:78
作者:

Jeschke, Marc G.
论文数: 0 引用数: 0
h-index: 0
机构:
Sunnybrook Hlth Sci Ctr, Ross Tilley Burn Ctr, 2075 Bayview Ave,Rm D704, Toronto, ON M4N 3M5, Canada
Univ Toronto, Dept Surg, Div Plast Surg, Toronto, ON, Canada
Univ Toronto, Dept Immunol, Toronto, ON, Canada Sunnybrook Hlth Sci Ctr, Ross Tilley Burn Ctr, 2075 Bayview Ave,Rm D704, Toronto, ON M4N 3M5, Canada
机构:
[1] Sunnybrook Hlth Sci Ctr, Ross Tilley Burn Ctr, 2075 Bayview Ave,Rm D704, Toronto, ON M4N 3M5, Canada
[2] Univ Toronto, Dept Surg, Div Plast Surg, Toronto, ON, Canada
[3] Univ Toronto, Dept Immunol, Toronto, ON, Canada
基金:
美国国家卫生研究院;
关键词:
TRACE-ELEMENT SUPPLEMENTATION;
BURNED PEDIATRIC-PATIENTS;
GROWTH-HORMONE TREATMENT;
FREE FATTY-ACIDS;
ENDOPLASMIC-RETICULUM STRESS;
RESTING ENERGY-EXPENDITURE;
INSULIN-TREATMENT IMPROVES;
MUSCLE PROTEIN CATABOLISM;
ACUTE-PHASE RESPONSE;
GLUCOSE-METABOLISM;
D O I:
10.1097/BCR.0000000000000265
中图分类号:
R4 [临床医学];
学科分类号:
1002 ;
100602 ;
摘要:
Hypermetabolism is the ubiquitous response to a severe burn injury, which was first described in the nineteenth century. Despite identification of important components of this complex response, hypermetabolism is still not well understood in its entirety. This article describes this incredibly fascinating response and the understanding we have gained over the past 100 years. Additionally, this article describes novel insights and delineates treatment options to modulate postburn hypermetabolism with the goal to improve outcomes of burn patients.
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收藏
页码:86 / 96
页数:11
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[81]
Glucose Control in Severely Thermally Injured Pediatric Patients What Glucose Range Should Be the Target?
[J].
Jeschke, Marc G.
;
Kraft, Robert
;
Emdad, Fatemeh
;
Kulp, Gabriela A.
;
Williams, Felicia N.
;
Herndon, David N.
.
ANNALS OF SURGERY,
2010, 252 (03)
:521-528

Jeschke, Marc G.
论文数: 0 引用数: 0
h-index: 0
机构:
Shriners Hosp Children, Galveston, TX 77550 USA
Univ Texas Med Branch, Dept Surg, Galveston, TX USA Shriners Hosp Children, Galveston, TX 77550 USA

Kraft, Robert
论文数: 0 引用数: 0
h-index: 0
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Shriners Hosp Children, Galveston, TX 77550 USA
Univ Texas Med Branch, Dept Surg, Galveston, TX USA Shriners Hosp Children, Galveston, TX 77550 USA

Emdad, Fatemeh
论文数: 0 引用数: 0
h-index: 0
机构:
Shriners Hosp Children, Galveston, TX 77550 USA
Univ Texas Med Branch, Dept Surg, Galveston, TX USA Shriners Hosp Children, Galveston, TX 77550 USA

Kulp, Gabriela A.
论文数: 0 引用数: 0
h-index: 0
机构:
Shriners Hosp Children, Galveston, TX 77550 USA
Univ Texas Med Branch, Dept Surg, Galveston, TX USA Shriners Hosp Children, Galveston, TX 77550 USA

Williams, Felicia N.
论文数: 0 引用数: 0
h-index: 0
机构:
Shriners Hosp Children, Galveston, TX 77550 USA
Univ Texas Med Branch, Dept Surg, Galveston, TX USA Shriners Hosp Children, Galveston, TX 77550 USA

Herndon, David N.
论文数: 0 引用数: 0
h-index: 0
机构:
Shriners Hosp Children, Galveston, TX 77550 USA
Univ Texas Med Branch, Dept Surg, Galveston, TX USA Shriners Hosp Children, Galveston, TX 77550 USA
[82]
Intensive Insulin Therapy in Severely Burned Pediatric Patients A Prospective Randomized Trial
[J].
Jeschke, Marc G.
;
Kulp, Gabriela A.
;
Kraft, Robert
;
Finnerty, Celeste C.
;
Mlcak, Ron
;
Lee, Jong O.
;
Herndon, David N.
.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE,
2010, 182 (03)
:351-359

Jeschke, Marc G.
论文数: 0 引用数: 0
h-index: 0
机构:
Shriners Hosp Children, Galveston, TX 77550 USA
Univ Texas Med Branch, Dept Surg, Galveston, TX USA Shriners Hosp Children, Galveston, TX 77550 USA

Kulp, Gabriela A.
论文数: 0 引用数: 0
h-index: 0
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Shriners Hosp Children, Galveston, TX 77550 USA
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Univ Texas Med Branch, Dept Ophthalmol, Galveston, TX USA Shriners Hosp Children, Galveston, TX 77550 USA

Kraft, Robert
论文数: 0 引用数: 0
h-index: 0
机构:
Shriners Hosp Children, Galveston, TX 77550 USA
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Finnerty, Celeste C.
论文数: 0 引用数: 0
h-index: 0
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Shriners Hosp Children, Galveston, TX 77550 USA
Univ Texas Med Branch, Dept Surg, Galveston, TX USA Shriners Hosp Children, Galveston, TX 77550 USA

Mlcak, Ron
论文数: 0 引用数: 0
h-index: 0
机构:
Shriners Hosp Children, Galveston, TX 77550 USA
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Lee, Jong O.
论文数: 0 引用数: 0
h-index: 0
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Herndon, David N.
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h-index: 0
机构:
Shriners Hosp Children, Galveston, TX 77550 USA
Univ Texas Med Branch, Dept Surg, Galveston, TX USA Shriners Hosp Children, Galveston, TX 77550 USA
[83]
The Hepatic Response to Thermal Injury: Is the Liver Important for Postburn Outcomes?
[J].
Jeschke, Marc G.
.
MOLECULAR MEDICINE,
2009, 15 (9-10)
:337-351

Jeschke, Marc G.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas Med Branch, Shriners Hosp Children, Galveston, TX 77550 USA
Univ Texas Med Branch, Dept Surg, Galveston, TX 77550 USA Univ Texas Med Branch, Shriners Hosp Children, Galveston, TX 77550 USA
[84]
Effect of insulin on the inflammatory and acute phase response after burn injury
[J].
Jeschke, Marc G.
;
Boehning, Darren F.
;
Finnerty, Celeste C.
;
Herndon, David N.
.
CRITICAL CARE MEDICINE,
2007, 35 (09)
:S519-S523

Jeschke, Marc G.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas Med Branch, Shriners Hosp Children, Galveston, TX USA Univ Texas Med Branch, Shriners Hosp Children, Galveston, TX USA

Boehning, Darren F.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas Med Branch, Shriners Hosp Children, Galveston, TX USA

Finnerty, Celeste C.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas Med Branch, Shriners Hosp Children, Galveston, TX USA

Herndon, David N.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas Med Branch, Shriners Hosp Children, Galveston, TX USA
[85]
Insulin treatment improves the systemic inflammatory reaction to severe trauma
[J].
Jeschke, MG
;
Klein, D
;
Herndon, DN
.
ANNALS OF SURGERY,
2004, 239 (04)
:553-560

Jeschke, MG
论文数: 0 引用数: 0
h-index: 0
机构: Univ Regensburg Klinikum, Chirurg Klin & Poliklin, Regensburg, Germany

Klein, D
论文数: 0 引用数: 0
h-index: 0
机构: Univ Regensburg Klinikum, Chirurg Klin & Poliklin, Regensburg, Germany

Herndon, DN
论文数: 0 引用数: 0
h-index: 0
机构: Univ Regensburg Klinikum, Chirurg Klin & Poliklin, Regensburg, Germany
[86]
Insulin attenuates the systemic inflammatory response in endotoxemic rats
[J].
Jeschke, MG
;
Klein, D
;
Bolder, U
;
Einspanier, R
.
ENDOCRINOLOGY,
2004, 145 (09)
:4084-4093

Jeschke, MG
论文数: 0 引用数: 0
h-index: 0
机构: Univ Erlangen Nurnberg, Dept Surg, Erlangen, Germany

Klein, D
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h-index: 0
机构: Univ Erlangen Nurnberg, Dept Surg, Erlangen, Germany

Bolder, U
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h-index: 0
机构: Univ Erlangen Nurnberg, Dept Surg, Erlangen, Germany

Einspanier, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Erlangen Nurnberg, Dept Surg, Erlangen, Germany
[87]
Insulin prevents liver damage and preserves liver function in lipopolysaccharide-induced endotoxemic rats
[J].
Jeschke, MG
;
Rensing, H
;
Klein, D
;
Schubert, T
;
Mautes, AEM
;
Bolder, U
;
Croner, RS
.
JOURNAL OF HEPATOLOGY,
2005, 42 (06)
:870-879

Jeschke, MG
论文数: 0 引用数: 0
h-index: 0
机构: Shriners Hosp Children, Galveston, TX 77550 USA

Rensing, H
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h-index: 0
机构: Shriners Hosp Children, Galveston, TX 77550 USA

Klein, D
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h-index: 0
机构: Shriners Hosp Children, Galveston, TX 77550 USA

Schubert, T
论文数: 0 引用数: 0
h-index: 0
机构: Shriners Hosp Children, Galveston, TX 77550 USA

Mautes, AEM
论文数: 0 引用数: 0
h-index: 0
机构: Shriners Hosp Children, Galveston, TX 77550 USA

Bolder, U
论文数: 0 引用数: 0
h-index: 0
机构: Shriners Hosp Children, Galveston, TX 77550 USA

Croner, RS
论文数: 0 引用数: 0
h-index: 0
机构: Shriners Hosp Children, Galveston, TX 77550 USA
[88]
Increased expression of insulin-like growth factor-I in serum and liver after recombinant human growth hormone administration in thermally injured rats
[J].
Jeschke, MG
;
Chrysopoulo, MT
;
Herndon, DN
;
Wolf, SE
.
JOURNAL OF SURGICAL RESEARCH,
1999, 85 (01)
:171-177

Jeschke, MG
论文数: 0 引用数: 0
h-index: 0
机构: Shriners Hosp Children, Med Staff, Galveston, TX 77550 USA

Chrysopoulo, MT
论文数: 0 引用数: 0
h-index: 0
机构: Shriners Hosp Children, Med Staff, Galveston, TX 77550 USA

Herndon, DN
论文数: 0 引用数: 0
h-index: 0
机构: Shriners Hosp Children, Med Staff, Galveston, TX 77550 USA

Wolf, SE
论文数: 0 引用数: 0
h-index: 0
机构: Shriners Hosp Children, Med Staff, Galveston, TX 77550 USA
[89]
Insulinlike growth factor I plus insulinlike growth factor binding protein 3 attenuates the proinflammatory acute phase response in severely burned children
[J].
Jeschke, MG
;
Barrow, RE
;
Herndon, DN
.
ANNALS OF SURGERY,
2000, 231 (02)
:246-252

Jeschke, MG
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, Med Branch, Dept Surg, Shriners Burns Hosp, Galveston, TX 77550 USA

Barrow, RE
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas, Med Branch, Dept Surg, Shriners Burns Hosp, Galveston, TX 77550 USA Univ Texas, Med Branch, Dept Surg, Shriners Burns Hosp, Galveston, TX 77550 USA

Herndon, DN
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, Med Branch, Dept Surg, Shriners Burns Hosp, Galveston, TX 77550 USA
[90]
Recombinant human growth hormone alters acute phase reactant proteins, cytokine expression, and liver morphology in burned rats
[J].
Jeschke, MG
;
Herndon, DN
;
Wolf, SE
;
DebRoy, MA
;
Rai, J
;
Lichtenbelt, BJ
;
Barrow, RE
.
JOURNAL OF SURGICAL RESEARCH,
1999, 83 (02)
:122-129

Jeschke, MG
论文数: 0 引用数: 0
h-index: 0
机构: Shriners Hosp Crippled Children, Galveston, TX 77550 USA

Herndon, DN
论文数: 0 引用数: 0
h-index: 0
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Wolf, SE
论文数: 0 引用数: 0
h-index: 0
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DebRoy, MA
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h-index: 0
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Rai, J
论文数: 0 引用数: 0
h-index: 0
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Lichtenbelt, BJ
论文数: 0 引用数: 0
h-index: 0
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