The Type IVB secretion system: an enigmatic chimera

被引：57
作者：
Kubori, Tomoko [1 ]
Nagai, Hiroki [1 ]
机构：
[1] Osaka Univ, Microbial Dis Res Inst, Yamadaoka 3-1, Suita, Osaka 5650871, Japan
来源：
CURRENT OPINION IN MICROBIOLOGY | 2016年 / 29卷
关键词：
NUCLEOTIDE EXCHANGE FACTOR; GRAM-NEGATIVE BACTERIA; LEGIONELLA-PNEUMOPHILA; INTRACELLULAR GROWTH; HUMAN MACROPHAGES; CORE COMPLEX; VIRULENCE SYSTEM; PROTEIN COMPLEX; HOST-CELLS; GENES;
D O I：
10.1016/j.mib.2015.10.001
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Type IV secretion systems (T4SSs) are transporters that span the bacterial inner and outer membranes and deliver substrate biomolecules, including proteins and DNAs, into cells. Recent progress in structural analyses of conjugative plasmid-encoded type IVA secretion systems (T4ASSs) has revealed a unique molecular architecture. The essential virulence system, the Dot/lcm Type NB secretion system (T4BSS) encoded by the intracellular bacterial pathogen Legionella pneumophila is distantly related to T4ASSs. Molecular and structural analyses of the Dot/lcm T4BSS have provided insights into the mechanisms of assembly and function. Here we highlight the chimeric quality of T4BSSs that possess components with similarity to many bacterial secretion systems.
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页码：22 / 29
页数：8
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