Hydrophilic ligands derived from glucose: Synthesis, characterization and in vitro cytotoxic activity on cancer cells of Pt(II) complexes

被引：15

作者：

Cucciolito, Maria Elena ^{[1
]}

Del Litto, Raffaella ^{[1
]}

Fanizzi, Francesco Paolo ^{[2
]}

Migoni, Danilo ^{[2
]}

Roviello, Giuseppina ^{[1
]}

Ruffo, Francesco ^{[1
]}

机构：

[1] Univ Naples Federico 2, Dipartimento Chim, I-80126 Naples, Italy

[2] Univ Salento, DiSTeBA, Ctr Ecotekne, I-73100 Lecce, Italy

来源：

INORGANICA CHIMICA ACTA | 2010年 / 363卷 / 04期

关键词：

Platinum; Carbohydrate; Crystal structure; Cytotoxic activity; PLATINUM(II) COMPLEXES; AMINO-SUGARS; COORDINATION; DRUGS;

D O I：

10.1016/j.ica.2009.11.031

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Aiming to contribute to the design of new antitumoral drugs, we synthesized new hydrophilic Pt(II) complexes of general formula [PtCl2(N,N')] containing nitrogen bidentate amine-imine and di-imine ligands derived from glucose. Some chemical properties were discussed. The X-ray molecular structure of [PtCl2(alpha-D-glucopyranoside-methyl-6-deoxy-6(2-(methylimino) methyl) pyridine) (D) was reported. [Pt Cl-2(beta-D-glucopyranosylimine-N-(2-pyridinylmethyl))] (A), which is well-soluble both in organic solvents and in water, was tested for cytotoxicity. (C) 2009 Elsevier B. V. All rights reserved.

引用

页码：741 / 747

页数：7

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