On the Study of Sorption in the Chiral Separation of the Enantiomers of Salbutamol and Salmeterol by Supercritical Fluid Chromatography

被引：1

作者：

Mikushina, Irina, V ^{[1
]}

Bazarnova, Natalya G. ^{[1
]}

Parenago, Olga O. ^{[2
]}

Gensh, Konstantin, V ^{[1
]}

Cheprasova, Marina Yu ^{[1
]}

机构：

[1] Altay State Univ, 61 Lenin, Barnaul 656049, Russia

[2] Inst Gen & Inorgan Chem NS Kurnakova, 31 Leninsky Prospect, Moscow 119071, Russia

来源：

JOURNAL OF SIBERIAN FEDERAL UNIVERSITY-CHEMISTRY | 2019年 / 12卷 / 03期

关键词：

enantiomers; supercritical fluid chromatography; chiral separation; sorption mechanism; salbutamol; salmeterol;

D O I：

10.17516/1998-2836-0128

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The studied conditions of supercritical fluid chiral chromatography of salbutamol and salbutamol sulfate allowed to assumethe possibility ofionic interactions in the process ofseparation ofenantiomers. It is shown that the structure of the hydrocarbon radical of 1- (4-hydroxy-3- (hydroxymethyl) phenyl)-2-aminoethanol associated with the chiral fragment, and, consequently, the physicochemical characteristics of the substance molecule, such as the number of hydrogen donors and acceptors polar surface, significantly affect the ability to communicate with the sorbent selectors under conditions of supercritical fluid chromatography.

引用

页码：310 / 318

页数：9

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