Polypeptide Nanoparticles Obtained from Emulsion Polymerization of Amino Acid N-Carboxyanhydrides

被引：61

作者：

Jacobs, Jaco ^{[1
]}

Pavlovic, Drazen ^{[2
,6
]}

Prydderch, Hannah ^{[2
]}

Moradi, Mohammad-Amin ^{[3
,4
]}

Ibarboure, Emmanuel ^{[5
]}

Heuts, Johan P. A. ^{[3
,4
]}

Lecommandoux, Sebastien ^{[5
]}

Heise, Andreas ^{[2
]}

机构：

[1] Dublin City Univ, Sch Chem Sci, Dublin 9, Ireland

[2] Royal Coll Surgeons Ireland, Dept Chem, 123 St Stephens Green, Dublin 2, Ireland

[3] Eindhoven Univ Technol, Dept Chem Engn & Chem, POB 513, NL-5600 MB Eindhoven, Netherlands

[4] Eindhoven Univ Technol, Inst Complex Mol Syst, POB 513, NL-5600 MB Eindhoven, Netherlands

[5] Univ Bordeaux, CNRS, UMR 5629, Bordeaux INP,LCPO, F-33600 Pessac, France

[6] Almac Sci Ltd, Almac House,Seagoe Ind Estate, Craigavon BT63 5QD, North Ireland

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2019年 / 141卷 / 32期

基金：

爱尔兰科学基金会;

关键词：

DRUG-DELIVERY; PLGA NANOPARTICLES; NANOENCAPSULATION; DESIGN;

D O I：

10.1021/jacs.9b06750

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Polypeptide nanoparticles were obtained by the miniemulsion polymerization of S-(o-nitrobenzyl)-L-cysteine (NBC) N-carboxyanhydride (NCA). Through process optimization, reaction conditions were identified that allowed the polymerization of the water sensitive NCA to yield nanoparticles of about 220 nm size. Subsequent UV-irradiation of the nanoparticle emulsions caused the in situ removal of the nitrobenzyl group and particle cross-linking through disulfide bond formation accompanied by the shrinkage of the particles.

引用

页码：12522 / 12526

页数：5

共 36 条

[1] Tumor microenvironment-targeted poly-L-glutamic acid-based combination conjugate for enhanced triple negative breast cancer treatment [J].