Epigenetics of aging and disease: a brief overview

被引：76

作者：

Pagiatakis, Christina ^{[2
]}

Musolino, Elettra ^{[1
,3
]}

Gornati, Rosalba ^{[1
]}

Bernardini, Giovanni ^{[1
]}

Papait, Roberto ^{[1
,2
,3
]}

机构：

[1] Univ Insubria, Dept Biotechnol & Life Sci, Varese, Italy

[2] Humanitas Res Hosp, Dept Cardiovasc Med, Rozzano, MI, Italy

[3] Natl Res Council Italy, Genet & Biomed Res Inst, I-20089 Milan, Italy

来源：

AGING CLINICAL AND EXPERIMENTAL RESEARCH | 2021年 / 33卷 / 04期

关键词：

Epigenetics; Aging; Cardiovascular disease; Cancer; DNA METHYLATION; WIDE ASSOCIATION; OXIDATIVE STRESS; GENE-EXPRESSION; CANCER; DRUGS; HOMEOSTASIS; PROMOTERS; LANDSCAPE; SIGNATURE;

D O I：

10.1007/s40520-019-01430-0

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Aging is an important risk factor for several human diseases such as cancer, cardiovascular disease and neurodegenerative disorders, resulting from a combination of genetic and environmental factors (e.g., diet, smoking, obesity and stress), which, at molecular level, cause changes in gene expression underlying the decline of physiological function. Epigenetics, which include mechanisms regulating gene expression independently of changes to DNA sequence, regulate gene expression by modulating the structure of chromatin or by regulating the binding of transcriptional machinery to DNA. Several studies showed that an impairment of epigenetic mechanisms promotes alteration of gene expression underlying several aging-related diseases. Alteration of these mechanisms is also linked with changes of gene expression that occurs during aging processes of different tissues. In this review, we will outline the potential role of epigenetics in the onset of two age-related pathologies, cancer and cardiovascular diseases.

引用

页码：737 / 745

页数：9

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