An improvement of [11C]acetate synthesis -: non-radioactive contaminants by irradiation-induced species emanating from the [11C]carbon dioxide production target

被引：33
|
作者：
Roeda, D [1 ]
Dollé, F [1 ]
Crouzel, C [1 ]
机构：
[1] CEA, Serv Hosp Frederic Joliot, Dept Rech Med, F-91401 Orsay, France
来源：
APPLIED RADIATION AND ISOTOPES | 2002年 / 57卷 / 06期
关键词：
C-11]acetate synthesis; radiopharmaceutical quality; nitrogen oxides;
D O I：
10.1016/S0969-8043(02)00224-5
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
An existing procedure for [C-11]acetate synthesis, consisting of a reaction of methylmagnesium chloride and [C-11]carbon dioxide in tetrahydrofuran, hydrolysis and ion-exchange purification on small columns, has been improved. The use of less Grignard reagent and application of commercial cartridges instead of home made ones led to an increase of the overall yield from 60-65% to over 80%. Malfunction in pure nitrogen targets for C-11 production may lead to unexpected contaminants. It is recommended to incorporate in the target outlet line a trap for removal of nitrogen oxides. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：857 / 860
页数：4
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