A pathogenic role of plasmacytoid dendritic cells in autoimmunity and chronic viral infection

被引：49

作者：

Barrat, Franck J. ^{[1
,2
]}

Su, Lishan ^{[3
]}

机构：

[1] Hosp Special Surg, HSS Res Inst, Autoimmun & Inflammat Program, 535 E 70th St, New York, NY 10021 USA

[2] Cornell Univ, Weill Cornell Med Coll, Dept Microbiol, New York, NY 10021 USA

[3] Univ N Carolina, Sch Med, Lineberger Comprehens Canc Ctr, Dept Microbiol, Chapel Hill, NC 27515 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2019年 / 216卷 / 09期

基金：

美国国家卫生研究院;

关键词：

INTERFERON-PRODUCING CELLS; INDUCIBLE GENE-EXPRESSION; SCID-HU MOUSE; I INTERFERON; SIV INFECTION; HIV-1; INFECTION; LYMPH-NODES; BACTERIAL-INFECTIONS; IMMUNE ACTIVATION; PERIPHERAL-BLOOD;

D O I：

10.1084/jem.20181359

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Following the discovery of plasmacytoid dendritic cells (pDCs) and of their extraordinary ability to produce type I IFNs (IFN-I) in response to TLR7 and TLR9 stimulation, it is assumed that their main function is to participate in the antiviral response. There is increasing evidence suggesting that pDCs and/or IFN-I can also have a detrimental role in a number of inflammatory and autoimmune diseases, in the context of chronic viral infections and in cancers. Whether these cells should be targeted in patients and how much of their biology is connected to IFN-I production remains unclear and is discussed here.

引用

页码：1974 / 1985

页数：12

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