A pathogenic role of plasmacytoid dendritic cells in autoimmunity and chronic viral infection

被引：54

作者：

Barrat, Franck J. ^{[1
,2
]}

Su, Lishan ^{[3
]}

机构：

[1] Hosp Special Surg, HSS Res Inst, Autoimmun & Inflammat Program, 535 E 70th St, New York, NY 10021 USA

[2] Cornell Univ, Weill Cornell Med Coll, Dept Microbiol, New York, NY 10021 USA

[3] Univ N Carolina, Sch Med, Lineberger Comprehens Canc Ctr, Dept Microbiol, Chapel Hill, NC 27515 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2019年 / 216卷 / 09期

基金：

美国国家卫生研究院;

关键词：

INTERFERON-PRODUCING CELLS; INDUCIBLE GENE-EXPRESSION; SCID-HU MOUSE; I INTERFERON; SIV INFECTION; HIV-1; INFECTION; LYMPH-NODES; BACTERIAL-INFECTIONS; IMMUNE ACTIVATION; PERIPHERAL-BLOOD;

D O I：

10.1084/jem.20181359

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Following the discovery of plasmacytoid dendritic cells (pDCs) and of their extraordinary ability to produce type I IFNs (IFN-I) in response to TLR7 and TLR9 stimulation, it is assumed that their main function is to participate in the antiviral response. There is increasing evidence suggesting that pDCs and/or IFN-I can also have a detrimental role in a number of inflammatory and autoimmune diseases, in the context of chronic viral infections and in cancers. Whether these cells should be targeted in patients and how much of their biology is connected to IFN-I production remains unclear and is discussed here.

引用

收藏

页码：1974 / 1985

页数：12

相关论文

共 132 条

[51] Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9 [J].

Guiducci, Cristiana ;

Tripodo, Claudio ;

Gong, Mei ;

Sangaletti, Sabina ;

Colombo, Mario P. ;

Coffman, Robert L. ;

Barrat, Franck J. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2010, 207 (13) :2931-2942

[52] TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus [J].

Guiducci, Cristiana ;

Gong, Mei ;

Xu, Zhaohui ;

Gill, Michelle ;

Chaussabel, Damien ;

Meeker, Thea ;

Chan, Jean H. ;

Wright, Tracey ;

Punaro, Marilynn ;

Bolland, Silvia ;

Soumelis, Vassili ;

Banchereau, Jacques ;

Coffman, Robert L. ;

Pascual, Virginia ;

Barrat, Franck J. .

NATURE, 2010, 465 (7300) :937-U10

[53] Broadly Neutralizing Antibodies and Viral Inducers Decrease Rebound from HIV-1 Latent Reservoirs in Humanized Mice [J].

Halper-Stromberg, Ariel ;

Lu, Ching-Lan ;

Klein, Florian ;

Horwitz, Joshua A. ;

Bournazos, Stylianos ;

Nogueira, Lilian ;

Eisenreich, Thomas R. ;

Liu, Cassie ;

Gazumyan, Anna ;

Schaefer, Uwe ;

Furze, Rebecca C. ;

Seaman, Michael S. ;

Prinjha, Rab ;

Tarakhovsky, Alexander ;

Ravetch, Jeffrey V. ;

Nussenzweig, Michel C. .

CELL, 2014, 158 (05) :989-999

[54] Downregulation of Robust Acute Type I Interferon Responses Distinguishes Nonpathogenic Simian Immunodeficiency Virus (SIV) Infection of Natural Hosts from Pathogenic SIV Infection of Rhesus Macaques [J].

Harris, Levelle D. ;

Tabb, Brian ;

Sodora, Donald L. ;

Paiardini, Mirko ;

Klatt, Nichole R. ;

Douek, Daniel C. ;

Silvestri, Guido ;

Mueller-Trutwin, Michaela ;

Vasile-Pandrea, Ivona ;

Apetrei, Cristian ;

Hirsch, Vanessa ;

Lifson, Jeffrey ;

Brenchley, Jason M. ;

Estes, Jacob D. .

JOURNAL OF VIROLOGY, 2010, 84 (15) :7886-7891

[55] The toll-like receptor 7/8-ligand resiquimod (R-848) primes human neutrophils for leukotriene B4, prostaglandin E2 and platelet-activating factor biosynthesis [J].

Hattermann, Kim ;

Picard, Serge ;

Borgeat, Mathieu ;

Leclerc, Patrick ;

Pouliot, Marc ;

Borgeat, Pierre .

FASEB JOURNAL, 2007, 21 (07) :1575-1585

[56] IMMUNE INTERFERON IN THE CIRCULATION OF PATIENTS WITH AUTO-IMMUNE DISEASE [J].

HOOKS, JJ ;

MOUTSOPOULOS, HM ;

GEIS, SA ;

STAHL, NI ;

DECKER, JL ;

NOTKINS, AL .

NEW ENGLAND JOURNAL OF MEDICINE, 1979, 301 (01) :5-8

[57] Toll-Like Receptor Expression and Induction of Type I and Type III Interferons in Primary Airway Epithelial Cells [J].

Ioannidis, Ioannis ;

Ye, Fang ;

McNally, Beth ;

Willette, Meredith ;

Flano, Emilio .

JOURNAL OF VIROLOGY, 2013, 87 (06) :3261-3270

[58] Specialization, kinetics, and repertoire of type 1 interferon responses by human plasmacytoid predendritic cells [J].

Ito, T ;

Kanzler, H ;

Duramad, O ;

Cao, W ;

Liu, YJ .

BLOOD, 2006, 107 (06) :2423-2431

[59]

Jacobson JM, 2016, AIDS RES HUM RETROV, V32, P636, DOI [10.1089/aid.2015.0336, 10.1089/AID.2015.0336]

[60] Nonpathogenic SIV infection of African green monkeys induces a strong but rapidly controlled type I IFN response [J].

Jacquelin, Beatrice ;

Mayau, Veronique ;

Targat, Brice ;

Liovat, Anne-Sophie ;

Kunkel, Desiree ;

Petitjean, Gael ;

Dillies, Marie-Agnes ;

Roques, Pierre ;

Butor, Cecile ;

Silvestri, Guido ;

Giavedoni, Luis D. ;

Lebon, Pierre ;

Barre-Sinoussi, Francoise ;

Benecke, Arndt ;

Mueller-Trutwin, Michaela C. .

JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (12) :3544-3555

← 1 2 3 4 5 6 7 8 9 10 →