Myelodysplastic syndromes: the complexity of stem-cell diseases

被引：253
作者：
Corey, Seth J.
Minden, Mark D.
Barber, Dwayne L.
Kantarjian, Hagop
Wang, Jean C. Y.
Schimmer, Aaron D.
机构：
[1] Univ Texas, MD Anderson Canc Ctr, Dept Leukemia, Houston, TX 77030 USA
[2] Univ Texas, MD Anderson Canc Ctr, Div Pediat, Houston, TX 77030 USA
[3] Princess Margaret Hosp, Div Hematol & Oncol, Toronto, ON M4X 1K9, Canada
[4] Ontario Canc Inst, Toronto, ON M4X 1K9, Canada
[5] Ontario Canc Inst, Div Stem Cell & Dev Biol, Toronto, ON M4X 1K9, Canada
[6] Ontario Canc Inst, Div Cell & Mol Biol, Toronto, ON M4X 1K9, Canada
[7] Ontario Canc Inst, Div Genom & Proteom, Toronto, ON M4X 1K9, Canada
来源：
NATURE REVIEWS CANCER | 2007年 / 7卷 / 02期
基金：
加拿大健康研究院; 美国国家卫生研究院;
关键词：
D O I：
10.1038/nrc2047
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The prevalence of patients with myelodysplastic syndromes (MDS) is increasing owing to an ageing population and increased awareness of these diseases. MDS represent many different conditions, not just a single disease, that are grouped together by several clinical characteristics. A striking feature of MDS is genetic instability, and a large proportion of cases result in acute myeloid leukaemia (AML). We Review three emerging principles of MDS biology: stem-cell dysfunction and the overlap with AML, genetic instability and the deregulation of apoptosis, in the context of inherited bone marrow-failure syndromes, and treatment-related MDS and AML.
引用
收藏
页码：118 / 129
页数：12
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