Ultrasound-assisted synthesis of substituted guanidines from thioureas

被引：19

作者：

Pattarawarapan, Mookda ^{[1
]}

Jaita, Subin

Wangngae, Sirilak

Phakhodee, Wong

机构：

[1] Chiang Mai Univ, Dept Chem, Fac Sci, Chiang Mai 50200, Thailand

来源：

TETRAHEDRON LETTERS | 2016年 / 57卷 / 12期

关键词：

Guanidine; Thiourea; Cyanuric chloride; Triphenylphosphine; Ultrasound; HGCL2-PROMOTED GUANYLATION REACTION; SOLID-PHASE SYNTHESIS; EFFICIENT GUANYLATION; ORGANIC-SYNTHESIS; AMINES; 2,4,6-TRICHLORO-1,3,5-TRIAZINE; CARBODIIMIDES; CHEMISTRY;

D O I：

10.1016/j.tetlet.2016.02.050

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ultrasound-assisted synthesis of guanidine derivatives was developed using 2,4,6-trichloro-1,3,5-triazine as an inexpensive dehydrosulfurization reagent. Both 1,3-alkylaryl- and 1,3-diaryl-thioureas were rapidly converted into carbodiimides before subsequent reaction with aromatic or aliphatic amines. The method allows rapid access to highly substituted guanidines in good to excellent yields under mild conditions and with minimal use of solvent. (C) 2016 Elsevier Ltd. All rights reserved.

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页码：1354 / 1358

页数：5

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