RAS Proteins and Their Regulators in Human Disease

被引：1428

作者：

Simanshu, Dhirendra K. ^{[1
]}

Nissley, Dwight V. ^{[1
]}

McCormick, Frank ^{[1
,2
]}

机构：

[1] NCI, RAS Initiat, Canc Res Technol Program, Frederick Natl Lab Canc Res,Leidos Biomed Res, Frederick, MD 21701 USA

[2] Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, 1450 3rd St, San Francisco, CA 94158 USA

来源：

CELL | 2017年 / 170卷 / 01期

关键词：

GAP-RELATED DOMAIN; ONCOGENIC K-RAS; N-RAS; NEUROFIBROMATOSIS TYPE-1; H-RAS; SIGNAL-TRANSDUCTION; MEMBRANE-BINDING; STRUCTURAL BASIS; NOONAN SYNDROME; SMALL MOLECULES;

D O I：

10.1016/j.cell.2017.06.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

RAS proteins are binary switches, cycling between ON and OFF states during signal transduction. These switches are normally tightly controlled, but in RAS-related diseases, such as cancer, RASopathies, and many psychiatric disorders, mutations in the RAS genes or their regulators render RAS proteins persistently active. The structural basis of the switch and many of the pathways that RAS controls are well known, but the precise mechanisms by which RAS proteins function are less clear. All RAS biology occurs in membranes: a precise understanding of RAS' interaction with membranes is essential to understand RAS action and to intervene in RAS-driven diseases.

引用

页码：17 / 33

页数：17

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