Combined use of esmolol and nicardipine to blunt the haemodynamic changes following laryngoscopy and tracheal intubation

被引：24

作者：

Tan, PH

Yang, LC

Shih, HC

Lin, CR

Lan, KC

Chen, CS

机构：

[1] Chang Gung Mem Hosp, Dept Anaesthesiol, Niao Sung Hsiang, Kaohsiung Hsien, Taiwan

[2] Natl Sun Yat Sen Univ, Dept Biol Sci, Kaohsiung 80424, Taiwan

[3] Natl Yang Ming Univ, Sch Med, Vet Gen Hosp Kaohsiung, Dept Anaesthesiol, Taipei 112, Taiwan

来源：

ANAESTHESIA | 2002年 / 57卷 / 12期

关键词：

intubation : tracheal; sympathetic nervous system : alpha adrenergic antagonists; esmolol; calcium-channel blockers : nicardipine;

D O I：

10.1046/j.1365-2044.2002.02624_4.x

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

We examined the effect of different combinations of esmolol and nicardipine upon the circulatory response to tracheal intubation. One hundred patients were randomly allocated into five groups of twenty to receive pretreatments of saline or different combinations of esmolol (0.5 or 1.0 mg. kg(-1)) and nicardipine (15 or 30 mug. kg(-1)). Significant tachycardia persisted over a 5-min period after intubation in all five groups compared with baseline levels (p < 0.05). Patients receiving esmolol 1.0 mg.kg(-1) and nicardipine 30 mu g.kg(-1) showed no significant change in systolic blood pressure after tracheal intubation compared with baseline and significant lower peak systolic blood pressure than those receiving saline (p = 0.023).

引用

收藏

页码：1207 / 1212

页数：6

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