p53 pathways involving G2 checkpoint regulators and the role of their subcellular localisation

被引：0
|
作者：
Winters, ZE [1 ]
机构：
[1] Univ Bristol, Bristol Royal Infirm, Div Surg, Bristol BS2 8HW, Avon, England
来源：
JOURNAL OF THE ROYAL COLLEGE OF SURGEONS OF EDINBURGH | 2002年 / 47卷 / 04期
关键词：
G2; checkpoint; cyclin B/Cdc2; p53;
D O I：
暂无
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
DNA damage activates checkpoint pathways to produce a G1 or G2 cell cycle arrest and DNA repair. G2 checkpoint integrity prevents inappropriate mitosis of unrepaired DNA. Cell cycle progression is determined by cyclin-dependent kinase (CDK) enzymes in association with specific cyclin proteins, with Cdc2/cyclin B regulating mitosis. The tumour suppressor p53 re-enforces G2 arrest through the CDK inhibitor, p21(WAF1/CIP1). Functional regulation of G2 checkpoint proteins occurs through levels of protein expression, phosphorylation and subcellular localisation.
引用
收藏
页码：591 / 598
页数：8
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