Effects of metabolites of benzo(a)pyrene on unschedule DNA synthesis in BALB/3T3 cell line

被引：6

作者：

Chen, JK ^{[1
]}

Wu, ZL ^{[1
]}

Liu, YG ^{[1
]}

Lei, YX ^{[1
]}

机构：

[1] Guangzhou Med Coll, Inst Chem Carcinogenesis, Guangzhou 510182, Peoples R China

来源：

CHEMOSPHERE | 2000年 / 41卷 / 1-2期

关键词：

D O I：

10.1016/S0045-6535(99)00401-4

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

In order to explore the damage from metabolites of benzo(a)pyrene on DNA of mammalian cells, the effects of four metabolites of benzo(a)pyrene (anti-BPDE, syn-BPDE, 3-OH-BP and 9-OH-BP) on synthesis of DNA and unschedule DNA synthesis (UDS) in BALB/3T3 cells were assayed, by methods of single-labeling and double-labeling. The results showed that all of the four agents were able to increase the synthesis of DNA, but only three of them (apart from syn-BPDE) induced UDS in BALB/3T3 cells. The above indicates that the metabolites of benzo(a)pyrene are able to damage DNA in BALB/3T3 cells, and that this effect may be relative to the sterical structure of metabolites of benzo(a)pyrene. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：139 / 142

页数：4

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